Fused pyrimidines synthesis and anti-inflammatory testing of certainnovel imidazo [1,2-c] quinazoline, pyrimido [2,1-a] phthalazine derivatives

A number of heterocyclic compounds containing pyrimidine nucleus, namely, imidazo[l,2-c]quinazolines, pyrazolo[3,4-d]triazoIo[3.4-b]pyrimidines and pyrimido[2,1-a] phthalazines has been synthesized. Acidic moieties that characterize most of nonsteroidal antiinflammatory drugs [NSAIDs] or ester groups, as potential pro-drug functionaIities, have been incorporated. The potency of eight compounds to inhibit carrageenin-induced paw edema in rats has been evaluated