Synovial fluid collagenase and acid prosphatase in rheumatoid arthritis and osteoarthritis

Svnovial fluid from the knee joints of 3l rheumatoid arthritis [RA] patients [17 active and 14 inactive] and 27 patients with osteoarthritis [OA] were studied to detect the enzymatic activity of collagenase and acid phosphatase. The activity of both enzymes showed a significant increase in patients with active RA than those with inactive disease synovial fluid collagenase and acid phosphatase in RA patients Showed a significant correlation with ESR, morning stiffness, Pain Score, articular index and grip strength while an insignificant correlation with age and disease duration was recorded. There was a significant increase in the activity of both enzymes in RA patients when compared with OA patients