Résumé
cancer is one of the most frequent disease in the world and mutation has an important role in etiology of cancer [approximately 90%of mutagens are carcinogen]. Therefore Lab assistances that are working with mutagenic agents such as: Benzene, Xylazine and Formaldehyde for long period of time may be exposed to overload of these carcinogens. In Previous study, Mutagenicity test on urine sample of laboratory pathology technician of Tehran university medical sciences determined mutagenic agents activity. In regards to results, Mutagenicity assay was considered on forensic medicine laboratory of Tehran. Urine samples were collected at the end of the work shift and then were extracted by c18 column for the maximum concentration of pollutants. Then extracts were tested by TA100 and TA98 standard strains as well both with and without metabolic activator. Levels of toxicity and mutagenicity were detected by TA98 strain with activator in two personnel of pathology lab. Our results shows that forensic medicine pathology lab. worker have the same risk of cancer as the TUMS pathology lab. personals. I loecause smoking and other confounding factors not recorder false positive result is probably diseregarded in this study