Role of platelet distribution width and plateletcrit in assessment of nonthrombocytopenic preeclampsia and eclampsia in a tertiary care hospital of Odisha: an observational study

Background: Preeclampsia (PE) is a major cause of maternal and foetal morbidity and mortality in pregnancy. A decreased platelet count is observed during the progression of preeclampsia, and is considered a marker of the severity of preeclampsia. Considering the role of the PDW, PCT and platelet indices during the disease, the aim of this study was to evaluate the feasibility of using platelet indices as a severity marker for PE.Methods: This was a prospective, observational study, hospital-based study, from 2017-19 with 400 pregnant women being included on the basis of a predefined inclusion and exclusion criteria, through antenatal clinic, and labour room of the department of obstetrics and gynecology, S. C. B. Medical College, Cuttack, Odisha, India.Results: Study found that platelet count and plateletcrit showed a significant negative correlation with MAP whereas platelet distribution width showed a maximum positive correlation. In the preeclampsia group, subjects with PCT <0.22% were at risk of developing severe disease with a sensitivity of 53.5% and a high specificity of 85.5%. The AUC of 0.75 showed that it has a good predictability. In the eclampsia group, subjects with PCT <0.16% had a risk of developing severe disease with a sensitivity of 89.5% and specificity of 73.7%. The AUC 0.9 shows PCT to be a good predictor for assessing severity of eclampsia.Conclusions: This study suggests that platelet distribution width and plateletcrit are useful in risk evaluation of preeclampsia. These are a valid measurement tool to predict the severe progression of PE even when normal platelet counts are observed.

Pattern of chromosomal abnormalities in pediatric acute lymphoblastic leukemia [ALL]

To study the cytogenetic profile of newly diagnosed patients with pediatric acute lymphoblastic leukemia [ALL]. Prospective case control study. Tertiary care hospital in India. Newly diagnosed patients with pediatric ALL. Karyotype analysis of bone marrow aspirate samples by routine G-Banding technique and analysis as per International System for Cytogenetic Nomenclature [ISCN], 2005 criteria. Cytogenetic parameters. The study included 23 male and eight female patients [M:F = 2.8:1]. ALL-L2 was the most common morphlogical phenotype [18 / 31, 58%]. Sixteen out of thirty one [51.6%] patients were hypodiploid [2n < 46], 10 / 31 [32.0%] hyperdiploid [2n >46] and 5/ 31 [16.0%] aneuploid. Among hypodiploid groups, nine [29.0%] had modal chromosome number as 40-45, five [16.0%] as 31-39 and two [6.5%] as 25-30. Among hyperdiploid group, 7 [22.5%] had modal chromosome number as 51-60 followed by 2n = 47-50 [three patients, 6.5%]. The chromosomes [Chr] 2, 10, 12, 15, 17, 19 gain of Chr 4, 8, 10, 14 and 20 were observed in hyperdiploid group. Translocation t [10;14], t [9;22], t [2;22], t [8;22] and t [4;11] were seen in 04 [12.8%], 03 [9.6%], 02 [6.4% each] and one patient [3.2%] respectively. Adverse cytogenetic parameters such as hypodiploidy and translocations such as t [10;14], t [9;22], t [2;22], t [8;22] and t [4;11] were more common in our cohort of patients

Cytodiagnosis of granular cell tumor: a case report.

A young male aged 28 years presented with a subcutaneous nodule in the left arm. Fine needle aspiration diagnosis was benign granular cell tumor which was confirmed by histopathology. Since it is an uncommon tumor, of controversial histogenesis, it is being reported here.

Endovascular papillary angioendothelioma in an elderly female.

Endovascular papillary angioendothelioma (EPA) is a rare vascular tumor of low grade malignancy, encountered primarily in children. However some cases have also been reported in adults. A sixty year old female with EPA is described here. She presented with a swelling in the neck. Total surgical excision was performed. Histomorphology revealed anastomosing lymphatic channels showing intraluminal papillary fronds with hyaline vascular cores and hobnailing of endothelial cells. A diagnosis of EPA was made based on this picture. This tumor is recurrent and nodal metastasis has been reported in some cases.