Résumé
Objective: To evaluate the association of lymph node retrieval and ratio with the prognosis of colon cancer
Study Design: A cohort study
Place and Duration of Study: Ninewells Hospital and Medical School, Dundee, UK, from October 2014 to March 2015
Methodology: Data was collected for adult patients who were diagnosed with primary adenocarcinoma of colon between 2003 and 2008. The follow-up period was 5-year. The data was collected from regional electronic colorectal cancer database. Kaplan-Meier graph was used to calculate and depict overall survival in different groups of patients
Results: There were a total of 370 patients with colon cancer. For Dukes stages A and B, there was no significant difference in median overall survival for patients with lymph node retrieval [< 12 nodes vs. > 12 nodes]. For Dukes stage C [n=147], median survival for patients with lymph node retrieval < 12 nodes was 4 years vs. 4 years for patients with lymph node retrieval > 12 nodes [p = 0.85]. Median survival for patients with lymph node ratio [LNR] < 0.125 was 4 years [range 1 -11] vs. 3 years [range 0 -11] for patients with LNR > 0.125 [p = 0.14]. There was no significant difference in the recurrence rate based on lymph node retrieval [p = 0.87] and LNR [p = 0.97]
Conclusion: Lymph node retrieval > 12 and reduced LNR < 0.125 had no significant effect on long-term survival and recurrence of colon cancer