Relationship between histone modification and seizures in rat brain

To see the effect of progesterone on GABA transporter-1 and glutamate transporter-2 expression in the cerebral contex of developing rats after recurrent seizures. Quasit experimental study. This study was carried out in Experimental laboratory at Pediatrics Department, Xiangya 2[nd] Hospital, Central South University Changsha Human P.R. China, from September 2011 to April 2011. This experiment included 90 PN-7d the SD rats, Flurothyl to cause convulsions in group and progesterone in the intervention group, one died, died of status epilepticus, a mortality rate of 2.2% in each group were randomly selected eight test SD rats [72] for the analysis of experimental results. Flurothyl induced seizures stopped after the group of SD rats had no spontaneous seizures is the emergence of limb movement disorder and abnormal reactions. The cerebral cortex GAT-1 immunohistochemistry AOD changes in the control group, PN-13D [ARS-1d], the PN-15d [ARS-3d] and PN-19d Service [ARS-7d], the convulsions rats cerebral cortex GAT-1 immunohistochemistry AOD expression than the control group was significantly higher [P<0.01]; progesterone in the intervention group, the GAT-1 immunohistochemistry AOD than the convulsions were significantly lower [P<0.01] difference between the groups is not significant. The cerebral cortex GAT-1 protein expression was significantly higher and progesterone in the intervention group [P<0.01]; progesterone at each time point after the intervention of the GAT-1 expression levels than the control groups was significantly increased statistically significant [P<0.01]. Changes of expression of the GLT-1 protein in the rat cerebral cortex in the control group, the PN-13d, PN-15d and PN 19d cerebral cortex of the GLT-1 protein expression was no significant difference [F= 1, 852, P= 0.182]. In conclusion, Progesterone through its participation in regulation of neonatal recurrent seizures caused by an imbalance in the brain cerebral cortex, GAT-1, GLT-1 expression, the maintance of the central nervous system excitation-inhibition of the balance of the system, which play an anticonvulsant effect

Frequency of low birth weight in primigravida reported PUMHS hospital Nawabshah

To determine the frequency of low birth weight in primigravida reported at PMC Hospital Nawabshah. Descriptive case series study. Departments of Gynaecology and Obstetrics and paeds medicine, at Peoples University of Medical and Health Sciences Nawabshah, from Jan 2011 to the Dec 2011. this study consisted of 319 pregnant women at 16 weeks of gestational age with singleton pregnancy reporting to the Antenatal Clinic, Obstetrics and Gynaecology Department were selected. Weight was measured by using weight machine throughout antenatal checkups. Weight and height was measured by same person rechecked. Their pregnancies were followed to assess the low birth weight. The neonatologist evaluated the babies. All primigravida women in the reproductive age group between >18 to <35 years with singleton pregnancy, normal fetal lie, and Height 5 feet or more were included. Exclusion criteria were patients associated with uterine anomalies [like uterine polyp, uterine septae, submucosal fibroid], smoking, short stature, other medical disorder like diabetes, hypertension, thyroid disorders, epilepsy and asthma. Results were prepared with help of tables and graphs. Data was analyzed through SPSS software. 319 patients included in this study. There was a wide variation in age was noted. The youngest patient was 18 years old and the oldest patient was 35 years old. The mean age was 21.21 + 4.22 years and peak age group for presentation of primigravida in our study is 26 to 30 years. clinical asses the fetal weight and observed 42 [13.16%] cases were <3.5kg weight while remaining 277[86.83%] cases were 2.5 to 4 kg weight. In conclusion, we observed in our study that low body weight of primigravida mother is associated with low birth weight babies