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1.
Braz. j. med. biol. res ; 40(11): 1557-1565, Nov. 2007. graf, tab
Article Dans Anglais | LILACS | ID: lil-464316

Résumé

The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of high LV end-diastolic pressure (>12 mmHg) soon after MI. Cut-off values of 1.77 for the E/A ratio (P = 0.001) identified rats with elevated LV end-diastolic pressure with 90 percent sensitivity and 80 percent specificity. Cut-off values of 20.4 for the E/Em ratio (P = 0.0001) identified rats with elevated LV end-diastolic pressure with 81.8 percent sensitivity and 80 percent specificity. Moreover, E/A and E/Em ratios were the only echocardiographic parameters independently associated with LV end-diastolic pressure in multiple linear regression analysis. Therefore, DE identifies rats with high LV end-diastolic pressure soon after MI. These findings have implications for using serial DE in animal selection and in the assessment of their response to experimental therapies.


Sujets)
Animaux , Femelle , Rats , Hémodynamique/physiologie , Infarctus du myocarde/physiopathologie , Dysfonction ventriculaire gauche , Modèles animaux de maladie humaine , Échocardiographie-doppler , Infarctus du myocarde/complications , Infarctus du myocarde , Rat Wistar , Reproductibilité des résultats , Dysfonction ventriculaire gauche/étiologie
2.
Braz. j. med. biol. res ; 39(5): 687-695, May 2006. tab, graf
Article Dans Anglais | LILACS | ID: lil-425783

Résumé

Although echocardiography has been used in rats, few studies have determined its efficacy for estimating myocardial infarct size. Our objective was to estimate the myocardial infarct size, and to evaluate anatomic and functional variables of the left ventricle. Myocardial infarction was produced in 43 female Wistar rats by ligature of the left coronary artery. Echocardiography was performed 5 weeks later to measure left ventricular diameter and transverse area (mean of 3 transverse planes), infarct size (percentage of the arc with infarct on 3 transverse planes), systolic function by the change in fractional area, and diastolic function by mitral inflow parameters. The histologic measurement of myocardial infarction size was similar to the echocardiographic method. Myocardial infarct size ranged from 4.8 to 66.6 percent when determined by histology and from 5 to 69.8 percent when determined by echocardiography, with good correlation (r = 0.88; P < 0.05; Pearson correlation coefficient). Left ventricular diameter and mean diastolic transverse area correlated with myocardial infarct size by histology (r = 0.57 and r = 0.78; P < 0.0005). The fractional area change ranged from 28.5 ± 5.6 (large-size myocardial infarction) to 53.1 ± 1.5 percent (control) and correlated with myocardial infarct size by echocardiography (r = -0.87; P < 0.00001) and histology (r = -0.78; P < 00001). The E/A wave ratio of mitral inflow velocity for animals with large-size myocardial infarction (5.6 ± 2.7) was significantly higher than for all others (control: 1.9 ± 0.1; small-size myocardial infarction: 1.9 ± 0.4; moderate-size myocardial infarction: 2.8 ± 2.3). There was good agreement between echocardiographic and histologic estimates of myocardial infarct size in rats.


Sujets)
Animaux , Femelle , Rats , Échocardiographie-doppler , Contraction myocardique/physiologie , Infarctus du myocarde , Fonction ventriculaire gauche/physiologie , Remodelage ventriculaire/physiologie , Modèles animaux de maladie humaine , Infarctus du myocarde/anatomopathologie , Infarctus du myocarde/physiopathologie , Rat Wistar , Indice de gravité de la maladie
3.
Arq. bras. cardiol ; 70(5): 341-4, maio 1998. ilus
Article Dans Portugais | LILACS | ID: lil-218488

Résumé

A origem da artéria pulmonar direita em aorta ascendente é uma anomalia congênita rara, com poucos casos descritos na literatura. Descrevemos dois casos desta malforamçäo, um associado à interrupçäo de arco aórtico tipo B. Em ambos, o diagnóstico foi realizado mediante ecocardigrafia bidimensional, com confirmaçäo angiográfica em um. A origem da artéria pulmonar direita era próxima à valva aórtica, anomalia patogeneticamente diferente da origem perto da artéria inominada.


Sujets)
Nourrisson , Mâle , Nouveau-né , Aorte/malformations , Artère pulmonaire/malformations , Angiographie , Cathétérisme , Échocardiographie , Issue fatale , Période postopératoire
4.
Arq. bras. cardiol ; 69(5): 335-8, nov. 1997. ilus
Article Dans Portugais | LILACS | ID: lil-234363

Résumé

Descrevemos uma paciente de sete anos com diagnóstico ecocardiográfico e confirmação cirúrgica de endarterite de artéria pulmonar, citada como complicação da persistência do canal arterial e ilustramos a necessidade de ressecção cirúrgica completa do processo infeccioso para evitar outras complicaçöes, como embolia pulmonar.


Sujets)
Humains , Enfant , Femelle , Endocardite , Artère pulmonaire , Embolie pulmonaire , Valve du tronc pulmonaire , Hémogramme , Scintigraphie , Facteurs temps
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