RÉSUMÉ
Self reports of flushing reaction after drinking, cutaneous sensitivity to alcohol (patch test), and genotypic determination of ADH2, ADH3, and ALDH2 were studied in 53 Brazilian volunteers of different ethnic groups. Genotypes were determined using single strand conformation polymorphism in discontinous buffer electrophoresis. Analysis of the results indicated several cases of a reported flushing reaction among ALDH2 1/1 individuals, while all but 2 cases of ALDH2 heterozygotes reported a flushing reaction. The latter subjects also had negative result in the patch test. These preliminary results indicate that variability in the facial flushing reaction to alcohol seems to be a phenomenon resulting not only from the presence of a deficient ALDH2*2 allele, but also from other polymorphism of alcohol-metabolizing enzymes
Sujet(s)
Humains , Adulte , Éthanol/métabolisme , Ethnies , Rougeur de la face/ethnologie , Tests épicutanés , 38410 , Aldehyde oxidoreductases/métabolisme , Asiatiques , Brésil , 38413 , Génotype , Isoenzymes/métabolismeSujet(s)
Adolescent , Adulte , Adulte d'âge moyen , Humains , Mâle , Alcoolisme , Tests psychologiques , Enquêtes et questionnaires , BrésilRÉSUMÉ
Em funcao da controversia na literatura sobre a utilidade da administracao de niquetamida na intoxicacao alcoolica, foi realizado um trabalho experimental onde camundongos pre-tratados com 3,0/kg de etanol receberam niquetamida. Os resultados mostraram que o tempo de sono (perda do reflexo postural) sob a acao do etanol nao foi modificado pelo analeptico. Portanto, atraves do parametro utilizado, nao foi observada alteracoes da intoxicacao alcoolica pela niquetamida. Nos grupos que receberam as doses mais altas de niquetamida foram observadas convulsoes e mortes