Imunogenicidade da proteína M recombinante de Streptococcus equi subsp. equi coadministrada com um adjuvante molecular / Immunogenicity of recombinant M protein of Streptococcus equi subsp. equi co administered with a molecular adjuvant

The strangles is an infectious disease that affects horses from all ages and causes important economic losses in the equine-related business. The aim of this work was to evaluate the immunogenicity of the recombinant M protein from Streptococcus equi (rSeM) co-administered with the recombinant heat-labile enterotoxin B subunit from Escherichia coli (rLTB) in mice and horses. A total of 72 female Balb-c mice were divided into eight groups and 18 horses were divided into six groups. The animals were inoculated by intramuscular (IM) or intranasal (IN) routes with different treatments of rSeM, rLTB and/or Al(OH)3. The results obtained in both species, independent of administration routes, demonstrated that rSeM + rLTB had higher levels of specific serum immunoglobulins, however, in mucosal immunity the increase was not identified. Thus, the use of rSeM as vaccine antigen and rLTB as adjuvant can be a potential tool in the control of equine strangles.(AU)

Doenca mental e processos migratorios. / Mental disease and migratory process

Estudo preliminar realizado por uma equipe multidisciplinar do Setor de Psiquiatria Social da Escola Paulista de Medicina, com base na observacao participante de um grupo de familias migrantes nordestinas com ocorrencia de quadros psiquiatricos. Atraves de analise de alguns casos foi possivel supor que certas condutas, alem de "desviantes", seriam tambem respostas adequadas a situacoes concretas.Levanta-se a hipotese de que e preciso analisar as perturbacoes psiquicas desta populacao no contexto das correntes migratorias internas brasileiras, vinculando o que, na maioria das vezes, e visto exclusivamente do ponto de vista do individuo com processos sociais e culturais mais amplos