Penicillin-Induced Stevens–Johnson Syndrome: A Case Report.

Stevens–Johnson syndrome (SJS) is one of the manifestations of severe form of cutaneous adverse drug reactions (CADRs). Penicillin group of antibiotics is well-known to cause the CADRs. Few cases of amoxicillin and only one case of dicloxacillininduced SJS have been reported. To the best of our literature search, we have not come across a single case of amoxicillin– dicloxacillin-induced SJS. Here, we report a case of amoxicillin–dicloxacillin-induced SJS in a 28-year-old female patient. The rationality of amoxicillin–dicloxacillin fixed drug combination is doubtful. Hence, prescribing rational drug therapy and promptly reporting the adverse drug reactions is essential so that noncompliance to treatment with resultant therapeutic failure and augmented antimicrobial resistance can be avoided.

Cutaneous Drug Eruption Caused by Amoxicillin: A Case Report.

Amoxicillin is a commonly used antimicrobial agent to combat various infections. Penicillin group of drugs are known to cause cutaneous drug eruptions especially in pediatric population. Most of the time, these eruptions are mild in nature, however, sometimes they represent the early manifestation of rare, severe drug-induced cutaneous reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Here, we report a case of maculopapular, erythematous rash induced by amoxicillin in an 18-year-old male patient. The case is being reported to emphasize the need for efficient pharmacovigilance in order to motivate adverse drug reaction reporting so as to gather more and more data regarding adverse drug reactions.

Hypoglycemic and Hypolipidemic Activity of Mulberry (Morus Indica) in Type 2 Diabetes Patients.

Mulberry is known to have hypoglycemic, hypotensive and diuretic property. Andallu et al in 2001 have shown hypoglycemic, hypolipidemic and antioxidant activity of mulberry in comparative clinical trial with glibenclamide. Methods: Mild newly diagnosed patients of DM type 2, (having fasting blood sugar > 126 mg %) were randomized into 2 groups of 9 each .One of the groups received crude Mulberry (Morus Indica) leaves preparation of 1gm tds in capsule form and the other group received Glibenclamide 5 mg /day for a total study period of 30 days. Results: Within group (pre and post) analysis revealed, group receiving glibenclamide showed significant reduction in post meal blood sugar levels (p<0.05). Whereas group on Mulberry treatment demonstrated statistically significant decrease in fasting and post meal blood sugar levels (24.6% and 19.9% respectively; p<0.05), triglyceride (16.04%, p<0.05), VLDL (10.7%, p<0.05) and total cholesterol (10%, p<0.05) levels. This Mulberry wing also showed a decreasing trend in LDL and a rising trend in HDL levels, although statistically not significant. Mulberry group had more favourable effect on subjective symptoms eg, fatigability (90% vs 70%), sense of well-being (100% vs 60%) and cramps and leg pain (66.66% vs 42.9 %). Between group analysis (comparison for change in parameters). Both the groups did not show statistical difference when compared for change in parameters over one month. Conclusion: Mulberry (Morus Indica) has the potential to be useful in mild type 2 DM for its hypoglycemic and hypolipidemic action.

Modulatory effects of diltiazem on inotropic responses to amrinone on rabbit isolated atria.

The effect of pretreatment with graded concentration of diltiazem on the inotropic responses to amrinone were studied on isolated atria of rabbit. The responses to amrinone were modified by diltiazem in a biphasic manner; initial potentiation followed by inhibition. The potentiation is proposed to be due to synergistic rise in cytosolic calcium ion concentration by diltiazem and amrinone. The inhibition by diltiazem in higher concentration may be due to blockade of calcium ion influx and depletion of intracellular calcium ion from storage sites.