1.
Rev. méd. Chile
;
118(9): 965-70, sept. 1990. ilus
Article
Dans Espagnol
| LILACS
| ID: lil-96532
Résumé
We evaluated the role of oxygen free radicals in the induction of acute stress gastric ulcer in rats. After 12 hr of inmobility, ulcers of up to 4 mm were observed in the gastric mucosa. Pretreatment with allopurinol, a xantine oxydase inhibitor, produced a significant reduction in the number and size of lesions (p < 0.0001). No protection was afforded by aluminum hydroxyde or ranitidine alone, but enhanced protection was observed when given in association to allopurinol. A secondary role for H ions is suggested by these findings. Our results support the hypothesis of a role of a oxygen free radicals in the pathogenesis of stress gastric ulcers. Allopurinol might be used in conditions prodisposing to stress in patients
Sujets)
Rats , Animaux , Mâle , Femelle , Stress physiologique/complications , Ulcère peptique/étiologie , Allopurinol/pharmacologie , Oxygène , Lignées consanguines de rats , Ulcère peptique/induit chimiquement
2.
Rev. méd. Chile
;
114(9): 864-6, Sept. 1986. ilus
Article
Dans Espagnol
| LILACS
| ID: lil-44460