Successful treatment of chronic hepatitis C virus infection with peginterferon alpha-2a and ribavirin in patients with sickle cell disease

The objective of this case series was to determine the efficacy and safety of combined treatment with ribavirin and peginterferon alpha-2a in sickle cell disease [SCD] patients with chronic hepatitis C virus [HCV] hepatitis. Eight patients in King Abdulaziz Hospital and Oncology Center, Jeddah, Kingdom of Saudi Arabia from 2003 and 2006 with chronic HCV infection were treated with peginterferon alpha-2a and ribavirin for one year. All 8 patients had a complete early virological response. Seven out of 8 had an end of treatment response with undetectable HCV RNA at the end of therapy, 5 of whom also maintained a sustained virological response when assessed 6 months after the end of treatment. Hemoglobin concentrations measured at one, 3, 6, 9, and 12 months of treatment showed no significant changes from that measured as baseline. Treatment of chronic HCV hepatitis in patients with SCD with peginterferon alpha-2a and ribavirin seems safe and effective

Non-Compliance to Medication in Psychiatric Patients

To find out the frequency and reason for non-compliance to medication in a sample of psychiatric outpatients. It's a descriptive and cross sectional observation. The study was conducted in Government Hospital for Psychiatric Diseases, Lahore. A survey of outpatients was conducted, using a questionnaire designed for this purpose. Trained and experienced psychiatrists administered the questionnaire. The psychiatrists afterwards categorized the causes of discontinuation of medication. Total patients who were screened were 343, and among them 56 [16.32%] had stopped their medication. The commonest cause for discontinuation was inability to afford medication. Steady supply of medication to patients can improve the outcome of their illness