histopathological study of analgesic hepatotoxicity in rabbit

This study of analgesic hepatotoxicity was conducted on rabbit divided into four equal groups [A-D]. The group "A" served as control. The group "B" animals were administered acetylsalicylic acid [600 mg/Kg/day] orally, while group "C" animals received paracetamol [300 mg/Kg/day]. The group "D" was given both the acetylsalicylic acid [300 mg/Kg/day] and paracetamol [150 mg/I:g/day]. An autopsy was performed on all the animal groups at the end of 4 weeks. On gross and microscopic examination of liver sections, the control animals did not reveal any hepatic abnormality while the group "B" animals showed acute hepatitis [57%], acute cholangitis [14%] and focal necrosis [14%]. The group "C" revealed acute hepatitis in 86% cases. The group "D" receiving combination of drugs showed acute hepatitis [71%] and acute cholangitis [14%]. This study indicates that paracetamol is more toxic to liver as compared to acetylsalicylic acid in higher doses

experimental study of analgesic nephropathy in rabbit: a light microscopic study

This experimental study of analgesic nephropathy was conducted on rabbit divided into four equal groups [A, B, C, D]. Group A served as control. The drugs acetylsalicylic acid [Aspirin] 600 mg/Kg/day and Paracetamol [Acetaminophen] 300 mg/Kg/day alone as well as combination of Acetylsalicylic acid [300 mg/Kg/day] and Paracetamol [150 mg/Kg/day] were administered orally to groups B, C and D respectively for 4 weeks. After four weeks, the animals were sacrificed. Histopathological evaluation of renal tissue of each animal revealed that control group "A" animals did not show any abonormality. The acetylsalicylic acid treated group "B" showed acute pyelonephritis [71%], mild pyelitis [14%] and congestion of renal pelvis [14%]. The group "C" receiving paracetarnol revealed acute pyelonephritis [14%], acute pyelitis [43%], pelvic congestion [14%] and no change in 28% animals. The group "D" receiving combination of acetylsalicylic acid and Paracetamol showed interstitial nephritis [14%], acute pyelitis [14%], cloudy swelling [14%] and pelvic congestion in 43% animals. This study indicates that acetylsalicylic acid is more injurious to kidneys than paracetamol and these drugs do not have potentiating effect

effects of analgesics in therapeutic doses on the human urothelium

The effects of commonly used analgesics like acetylsalicylic acid and paracetamol in therapeutic doses on the urinary tract epithelium [urothelium] of 24 healthy male volunteers, divided into two groups of 12 volunteers each, were studied by administering acetylsalicylic acid and paracetamol in doses of 300 mg and 500 mg three times a day respectively for 5 days. A control group of 12 healthy volunteers was put on pharmacologically inactive placebo tablets. A slight, but not significant, increase in the urinary excretion of epithelial cells, leucocytes and red blood cells was observed in two groups of healthy volunteers receiving analgesics in usual therapeutic doses