Effects of partial devascularization of the adrenal cortex, with or without hypophysectomy, on the adrenal chromaffin cells

The effects of marked reduction in the concentration of the corticosteroids that reach the adrenal medulla, on the morphology of adrenal chromaffin cells, were studied in the rat. Necrosis of the adrenal cortex through partial devascularization, with or without hypophysectomy, were employed. It was found that the change in the metabolic activity of the adrenaline-storing cells into noradrenaline-storing cells could only be achieved after necrosis of the greater part of the adrenal cortex together with hypophysectomy