1.
Indian J Physiol Pharmacol
; 1985 Oct-Dec; 29(4): 250-4
Article
de Anglais
| IMSEAR
| ID: sea-107845
RÉSUMÉ
Effect of metronidazole (MNZ) treatment (oral and ip) on activities of cytochrome b5 and P-450 was studied in male, virgin and pregnant female mice. Activities of both the cytochromes increased in virgin mice treated with 2 mg (ip or PO, per mouse) but not in male and pregnant females. 30 mg dose (per mouse) was toxic in pregnant mice but increased the cytochromes activities in males and virgin females. HPLC analysis of liver MNZ levels showed that virgin females had higher MNZ content than male and pregnant females when treated with ip injection of MNZ (250 mg/kg).
Sujet(s)
Animaux , Cytochrome P-450 enzyme system/métabolisme , Cytochromes de type b/métabolisme , Cytochromes b5 , Femelle , Isoenzymes/métabolisme , Foie/effets des médicaments et des substances chimiques , Mâle , Métronidazole/pharmacologie , Souris , Grossesse
2.
Indian J Biochem Biophys
; 1985 Aug; 22(4): 223-5
Article
de Anglais
| IMSEAR
| ID: sea-26783
Sujet(s)
Animaux , Cytochrome P-450 enzyme system/métabolisme , Cytochromes de type b/métabolisme , Cytochromes b5 , Réplication de l'ADN/effets des médicaments et des substances chimiques , Induction enzymatique , Femelle , Lindane/pharmacologie , Foie/effets des médicaments et des substances chimiques , Mâle , Souris , Microsomes du foie/métabolisme , Ornithine decarboxylase/métabolisme , Biosynthèse des protéines
3.
Indian J Exp Biol
; 1985 Mar; 23(3): 145-8
Article
de Anglais
| IMSEAR
| ID: sea-58014