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1.
Braz. j. med. biol. res ; 29(10): 1291-9, Oct. 1996. tab, graf
Article Dans Anglais | LILACS | ID: lil-186176

Résumé

This study was designed to determine urinary sodium excretion in response to an oral glucose load in hypertensive patients. Fifteen hypertensive patients and eighteen normotensive subjects were studied after an overnight fast and for 4 h after the ingestion of 100 g glucose. A subgroup of intreated, nonobese, primary hypertensive patients (five of the 15 hypertensive patients) became hyperinsulinemic (total area under the insulin curve[TAUC]:33,080 + 3349 muU ml(-1) 120 min(-1) in response to an oral glucose load compared to normotensive subjects (TAUC: 3670<13.731<23,693 muU ml(-1) 120 min(-1) or to the other subgroup of normoinsulinemic hypertensive individuals (TAUC:10,221 + 1615 muU ml(-1) 120 min(-1) despite a similar serum glucose concentration in both groups. A significant decrease in renal sodium excretion in the entire hypertensive group (47.1 + 4.7 per cent, P<0.019) compared to the normotensive (20.0 + 10.5 per cent) subjects was also observed during the oral glucose tolerance test. Decreased renal sodium excretion was followed by a transient increase in urinary acid excretion. We speculate that the increase in insulin secretion may be responsible for the sodium-dependent increase in intracellular Ca2+, cellular H+ output and blood pressure in a subgroup of salt-sensitive patients with hypertension. New studies should be designed to identify the precise mechanisms involved in the interaction between hypertension, serum insulin-glucose levels and the magnitude of the renal tubule reabsorption abnormality.


Sujets)
Adulte , Femelle , Humains , Glucose/administration et posologie , Hypertension artérielle/complications , Insuffisance rénale/métabolisme , Sodium/métabolisme , Glycémie/métabolisme , Hyperinsulinisme/métabolisme
2.
Braz. j. med. biol. res ; 26(5): 491-5, May 1993. tab, graf
Article Dans Anglais | LILACS | ID: lil-148703

Résumé

This study was designed to investigate the behavior of serum glucose and insulin in response to an oral glucose load in chagasic patients with the indeterminate clinical form of the disease. Sixteen chagasic patients and 28 healthy control subjects were studied after an overnight fast and during 2 h after ingestion of 100 g glucose. There were no significant differences in serum glucose levels before and 2 h after the glucose load between chagasic and control subjects. However, in 8 chagasic patients, the total area under the insulin curve was significantly lower (2976 +/- 448 microU ml-1 120 min-1) than in the control (10123 +/- 995 microU ml-1 120 min-1) and in the remaining chagasic patients (9220 +/- 826 microU ml-1 120 min-1). These results suggest that the hypoinsulinemia of this subgroup of chagasic patients may be secondary to reduced insulin secretion and/or to increased peripheral insulin sensitivity probably related to autonomic dysfunction


Sujets)
Humains , Mâle , Femelle , Adulte , Glycémie/analyse , Maladie de Chagas/sang , Glucose/administration et posologie , Insuline/sang , Hyperglycémie provoquée , Insuline/métabolisme
3.
Braz. j. med. biol. res ; 23(12): 1253-7, 1990. tab
Article Dans Anglais | LILACS | ID: lil-103652

Résumé

To determine the possible existence of a relationship between insulin resistance and sympthetic nervous system activity in essential hypertension, we calculated the double cross index for 14 hypertensive sujects and 14 normotensive subjects submitted to the oral glucose test. Plasma glucose and insulin levels were similar in hypertensive and normotensive subjects. After glucose loading, however, both parameters were significantly higher in hypertensive subjects. Five out of 14 hypertensive patients were hyperinsulinemic. The increase in double cross index following a glucose load was significantly higher in normotensive volunteers than in hyperinsulinemic hypertensive subjects. No change in double cross index was observed in normoinsulinemic hypertensive subjects. Thus, insulin resistance, high blood glucose level, impairment of cardiac response and hyperinsulinemia are present in a significant portion of hypertensive patients. Hyperinsulinemia may contribute to hypertensión by stimulating sympathetic nervous system activity, by influencing the calcium transport across the cell membrane and/or by some other mechanism


Sujets)
Humains , Mâle , Femelle , Glycémie/analyse , Hypertension artérielle/étiologie , Insulinorésistance , Insuline/sang , Système nerveux sympathique/physiopathologie , Calcium/métabolisme , Hyperglycémie provoquée
5.
Article Dans Portugais | LILACS | ID: lil-7376

Résumé

Para verificar se existe correlacao entre os anticorpos EVI e NP e a infeccao chagasica cronica, foram estudados 56 pacientes sorologicamente positivos para o T. cruzi,que apresentavam diferentes formas clinicas desta infeccao. Foram tambem estudados 75 soros com reacoes negativas para T. cruzi, para determinar os titulos de EVI e NP que nao pertencem a esta populacao. Os resultados demonstram que titulo > ou igual a 1:32 podem ser tomados como positivos tanto para EVI quanto para NP. Considerando este titulo, verificamos que 69,6% e 70,1% dos pacientes chagasicos apresentam anticorpos EVI e NP respectivamente, e somente 3% dos individuos nao infectados apresentavam titulos de 1:32. Estes dados mostram a estreita relacao existente entre EVI, NP, e a infeccao chagasica. Porem, quando se analisou a presenca desses anticorpos em pacientes com as diferentes formas clinicas da doenca, nao foi encontrada diferenca significativa entre os grupos estudados


Sujets)
Anticorps , Maladie de Chagas , Cardiomyopathie associée à la maladie de Chagas
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