Résumé
A 41 year old female patient reported with the complaint of pain in the right posterior mandibular region for the past 5 months. History revealed that patient was diagnosed with breast cancer before 4 years following which she underwent mastectomy, radiotherapy and chemotherapy. PET / CT taken post chemotherapy showed bone metastasis to the lumbar spine for which she was prescribed I.V. zoledronic acid to be administered every 3 months. Patient was under I.V. zoledronic acid for a total of 36 months.Patient underwent surgery for extraction of impacted lower third molar before 7 months. The extraction site did not completely heal following which the tooth adjacent to the extraction site became mobile. The mobile tooth was also extracted before 5 months following which she developed pain and swelling in the region. Patient was diagnosed with osteoradionecrosis and underwent curettage and antiseptic dressing for 2 months. However, there was no reduction in pain. Pain was gradual in onset, continuous, gnawing, in the extraction site, aggravated by mastication and relieved by medication.
Résumé
Saliva is a biological fluid with multifactorial functional applications with regards to themaintenance of general health. Collection of saliva is non-invasive, easy and cost-effective. Xerostomia, a subjective sensation of dry mouth is one of the most common complaints in elderly and patients on polypharmacy as it is proven as a risk factor. Polypharmacy is the simultaneous use of multiple drugs by a patient for more than one systemic disease. Theaim of the study was to assess the salivary changes in patients on polypharmacy. Unstimulated saliva samples were collected from 20 individuals who reported to the Department of Special Care Dentistry at Saveetha Dental College between November to December 2019.The collected samples were then processed for analysis of three salivary parameters-Salivary glucose, amylase and pH. The data were recorded and statistically analyzed. Out of the 20 samples,12 male (60%) and 8 female(40%) with mean age group as 41.2 years. Independent t test showed statistically significant (p<0.05) values for salivary parameters in patients on polypharmacy medication. This study has shown a significant increase in salivary parameters and further studies relating the salivary changes, systemic disease and the medication involved salivary analysis can be suggested as one of the investigations in patients on polypharmacy.