RÉSUMÉ
Background: The purpose of this study was to assess factors associated with human immunodeficiency virus (HIV) pre-exposure prophylaxis uptake and retention among sex workers in Nakuru town, Kenya. The theory of planned behavior and the acquired immunodeficiency syndrome (AIDS) risk reduction model served as the study's theoretical framework. Methods: A cross-sectional research design was adopted for this study. The study targeted all the sex workers in Nakuru town who were 18 years old and above. A random sampling technique was used to get the hotspots where the sex workers were to be found. Snow balling sampling technique was then adopted to identify and recruit the study participants. Using primary sources. The quantitative data was obtained from the respondents using a questionnaire. Quantitative data was analyzed using descriptive and inferential statistics (regression analysis). The findings presented in table and graphical formats. Results: The analysis using multiple linear regression indicated that there was a collective significant effect between the awareness, health system factors, socio economic individual factors and use of pre-exposure prophylaxis (PrEP) among sex workers. A further analysis showed that, put together, the four predictor variables explained 35.7% of variation on PrEP uptake and retention. Conclusions: The study concluded that while use and none use PrEP can be explained by the four factors evaluated in this study, there are a lot of other factors that influence utilization of PrEP.