Résumé
Since Cookson et al. first reported the association of atopy with chromosome 11q13 in 1989, there have been numerous studies of genetics for allergic diseases. Their aim is to identify genetic factors modifying susceptibility to allergic diseases, determining the severity of disease in affected individuals and affecting the response to treatment. With these efforts, allergic diseases can be termed complex genetic disorders, defined as disorders that have numerous contributing genes, each having variable degrees of involvement in any given individual. This review aims to provide information on the current state of genetic research in Korean pediatric allergic diseases.
Sujets)
Enfant , Humains , Asthme , Recherche génétique , Génétique , Hypersensibilité , Corée , PédiatrieRésumé
Chitin, the second most abundant polysaccharide in nature after cellulose, consist exoskeleton of lower organisms such as fungi, crustaceans and insects except mammals. Mammalian chitinase and chitinase-like proteins (CLPs) are a family of mediators increasingly associated with infection, T cell-mediated inflammation, wound healing, allergy and asthma. Although our current knowledge of the function of mammalian chitinases and CLPs is very limited, important information can be deduced from research carried out in lower organisms, and in different immunopathological conditions. It is most striking that both chitinases and CLPs are up- regulated in T-helper type 2 (Th2)-driven conditions, and the first evidence is now emerging that these proteins may accentuate Th2 reactivity, and possibly contribute to the repair process that follows inflammation. In addition, regulatory SNPs in CHI3L1 were associated with asthma, atopy, and immunemediated diseases. In this review, recent findings on the role of chitinase and CLPs in allergic inflammation will be highlighted and the genetic studies in the genes encoding CHI3L1 will be discussed.
Sujets)
Humains , Asthme , Cellulose , Chitine , Chitinase , Champignons , Hypersensibilité , Inflammation , Insectes , Mammifères , Polymorphisme de nucléotide simple , Protéines , Grèves , Cicatrisation de plaieRésumé
Chitin, the second most abundant polysaccharide in nature after cellulose, consist exoskeleton of lower organisms such as fungi, crustaceans and insects except mammals. Mammalian chitinase and chitinase-like proteins (CLPs) are a family of mediators increasingly associated with infection, T cell-mediated inflammation, wound healing, allergy and asthma. Although our current knowledge of the function of mammalian chitinases and CLPs is very limited, important information can be deduced from research carried out in lower organisms, and in different immunopathological conditions. It is most striking that both chitinases and CLPs are up- regulated in T-helper type 2 (Th2)-driven conditions, and the first evidence is now emerging that these proteins may accentuate Th2 reactivity, and possibly contribute to the repair process that follows inflammation. In addition, regulatory SNPs in CHI3L1 were associated with asthma, atopy, and immunemediated diseases. In this review, recent findings on the role of chitinase and CLPs in allergic inflammation will be highlighted and the genetic studies in the genes encoding CHI3L1 will be discussed.