Résumé
Background and Objective: Epilepsy is a common neurological disorder. Plantago major [P.major] is used in traditional medicine due to flovonoids and vitamic C and antioxidant properties. This study was done to evaluate the hydro alcoholic extract of Plantago major L. on pentilentetrazol-induced seizures in male mice
Methods: In this experimental study, 50 NMRI male mice randomly allocated into control and four experimental groups. Seizures in animals induced by 60 mg/kg/bw of pentilentetrazol [PTZ], interperitoneally. Animals in experimental groups were received 5, 10, 25 and 50 mg/kg/bw of hydro alcoholic extract of Plantago major L. 30 min before each PTZ injection. The animals in control group were received saline, interperitoneally. After treatment, the behavior of animals during 20 minutes and mortality rate were recorded
Results: Seizure threshold of animals significantly increased in experimental groups which were received 50, 25, 10 mg/kg/bw of P.major extract in comparision with controls [P<0.05]. Mortality rate of animals significantly reduced in experimental groups which were received 50, 25, 10 mg/kg/bw of P, major extract in comparision with controls [P<0.05]
Conclusion: The hydro-alcoholic extract of Plantago major L. reduces seizure threshold in pentilentetrazol-induced seizures mice
Résumé
Silver nanoparticles with excellent antimicrobial effects and increasing consumption in different industries are the most widely used nanoparticles and so it is necessary to evaluate the safety of their use. This study has examined the effects of time and consumption dose of these particles on rats of Vistar race. 36 Vistar race rats after 4 weeks equalization period divided into 6 groups [one control and five tests] and were received 95ppm, 65ppm, 35ppm, 20ppm, 5ppm concentrations of silver nano [Nanocid L2000] solution from NANONASB-E-PARS CO. as water. After 3 and 6 months 3 animals of each group were selected and hormonal parameters were determined by CLIA method, Hb and HCT was measured by common Med. Lab. Kits and blood cells counted by H1 equipment. Finally, results were processed by one-side variance and tukey's test. The results indicated that white blood cells counting show meaningful dose dependent decreasing in number of these cells. No tangible change was seen on counting of red blood cells and the level of hemoglobin and hematocrit parameters. Also blood cortisol and T4 level of dependent dose decreased and Testosterone increased meaningfully. Water uptake index increasing happened in meaningful and dose dependent manner. Ketone bodies appeared in rats' urine that had eaten high doses of silver nano. WBC count decreasing after oral consumption of silver nano particles show cell apoptosis and immunity lowering. Also the particles have no effect on bone marrow function indexes. On the other hand, lowering the function of adrenal gland, hypothyroidism, increasing in sexual hormone level are side effects of these particles consumption. In addition, increasing in Water Uptake Index and urine volume can be for high blood pressure or kidney failure caused by these particles