[Experimental production and initial imaging of [18 F]-14-Fluoro-6-thia-hepatadecanoic acid [[18F]-FTHA] for myocardial performance]

[18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier-added [n.c.a] form from C in Benzyl-14-tosyloxy-6-thia-heptadecanoate 1 in one step at 90 Kryptofix2.2.2/[18F] and acetonitrile as the solvent followed by Silica column chromatography. The radiolabeled ester 2 was then hydrolyzed to yield [18F]-6-thia-14-fluoro-heptadecanoic 3b. The final solution was concentrated using C18 SPE system and administered to normal rats for biodistribution as well as co-incidence imaging studies. The synthesis took 15 min with overall radiochemical yield of 15-25% [EOS] and chemical-radiochemical purity more than 94%. Automation was performed using a two-pot synthesis. The best imaging time was shown to be 140-180 minutes post injection. Using this procedure a fast, reliable, automated synthesis for the cordial PET tracer, i.e. [18F]-FTHA can be obtained without HPLC purification step

Dependence of quality of thallium - 201 on irradiation data

Thallium-201 is produced through 203Tl [p, 3n] 201pb 201Tl reaction by cyclotron. This radioisotope has known as one of the cyclotron radioisotopes which is used for myocardial perfusion in the coronary artery disease, Tl-201 after chemical purification and quality control in the form of 201Tl-chlorid is ready to send to the hospitals. In this work the effect of the proton energy on quality of Tl-201, was studied. Radionucleidic purity was determined by high purity Ge [HPGe] detector Gamma spectrometer, in production time and after one half-life [73h]. The targets were coated with Enriched Thallium-203 [97%]. The Variation of thickness of targets was 18.3 +/- 1.3micro m. The different energies of bombardment on quality of Tl-201 and Tl-200, Tl-202, and Pb-203 [as impurity] were studied. The results have shown that optimum energy for proton was 28.5 MeV. The variation energy of bombardment can change the purity of Tl-201 but all results were in the standard range according to the United States Pharmacopoeia [USP] and European Pharmacopoeia