Antimicrobial activities of some transition metal complexes of the 2,6-diacetyl pyridine schiff base of S,S-dimethyldithiocarbazate

New pentadentate Schiff base ligand of S,S-dimethyldithiocarbazate was prepared after condensing with 2,6-diacetyl Pyridine and its Ni[II], Cu[II], Zn[II] complexes were obtained while reacted with corresponding metal salts. The ligand and its metal complexes were screened for antimicrobial activity against plant microbes' viz. Aspergillus sp., Fusarium solani, Penicillium sp., Verticillum sp. and Rhizobium sp. Observed action was good to moderate against Aspergillus sp., F. solani, Penicillium sp. and Verticillum sp. while for Rhizobium sp. it was negative or minute. Metal chelation increased the inhibitory competence of the ligand in most of the cases

Aging and drug metabolism

Oral dosage forms must initially undergo dissolution, and although the decrease in stomach acid production which accompanies increasing age has sometimes been cited as a factor mitigating against adequate drug absorption, while there is no real evidence for such an effect. It is quite possible that the only clinically important aspect of gastric of gastri pH as regard drug absorption is that it affects gastric motility, with higher pH values favoring absorption by hastening the movement of stomach contents to the small intestine. The role of gastric pH in drug absorption has already been discussed in the previous attempts [Sultana and Arayne 1982]. The present review describes the progress that has been made in understanding the effect of age on drug handling system of the body and the implication that these changes have on the utility of pharmacological agents in treatment of old age patients