Résumé
The effect of manganese [0.03, 0.30 or 3.00 mg Mn[+2]/Kg], administered subcutaneously to male toads for three months, on mineral dispositions [Mn, Ca, Fe, Cu Mg, Zn, and inorganic phosphate] in blood, liver and kidney were examined. After this time of exposure, significant increases in Mn levels in the three tissues were observed. While Ca and Fe contents were reduced in the blood, liver and kidney, Ca content was increased only in the blood and reduced in the others. No alterations were found in other parameters
Sujets)
Distribution tissulaire , Animaux de laboratoireRésumé
The effectiveness of carbon tetrachloride [CC1[4]] on serum and liver enzyme activities as well as total serum bilirubin, cholesterol and triglyceride levels were investigated in the Egyptian toad after a single S.C. dose of 2.8 ml/kg. At 24 h. exposure period all the selected enzymes were stimulated in the serum, while the liver enzymes varied in their sensitivities to this toxicant. Total serum bilirubin was increased, while cholesterol and triglyceride levels were reduced
Sujets)
Animaux de laboratoireRésumé
Several attempts were made to determine the effective concentrations of metal ions that can protect toads from a lethal dose of carbon tetrachloride [5.066 ml CC[4]/kg]which represents 24 hr LD 100]. The most preferable concentrations were: 728.000, 168.108, 2.080, 1120.550, 180.196, 15.471 and 2.208 micro mol/kg. for manganese, cobalt, selenium, zinc, calcium, lead and mercury, respectively