Determination of loratadine and its tablets by H1 NMR spectrometry

A new method, involving the application of 1H-NMR spectrometry for the assay of loratadine and its tablets, is proposed. The 1H-NMR spectrum of loratadine in DMSO [d6] has a well-defined triplet [around delta 1.3 ppm] and a quartet [near delta 4.3 ppm] which are chosen for quantitative analysis. The method is based on comparing the integral of these signals to that of the sharp singlet of maleic acid at delta 6.5 ppm which is used as internal standard. The proposed method is simple and rapid, giving accurate and reproducible results when applied for the analysis of both authentic loratadine and its tablets. In addition, the 1H-NMR spectrum obtained helps in confirming the identity and purity of the drug

Determination of ibuprofen by 1H NMR spectrometry

A simple, accurate and specific 1[H] NMR Spectrometric procedure is proposed for the determination of ibuprofen. It is based on comparing the integral peak area of the aromatic protons of ibuprofen [centered at 7.1 ppm] to that of the sharp singlet maleic acid [positioned at 6.3 ppm] which is used as internal standard. Accurate and precise results were obtained upon analysis of both authentic ibuprofen as well as its tablets. On the other hand, the obtained NMR spectrum helps in checking the identity and purity of the drug