Synthesis of some N,N- [4,4-carbonyldiphthaloyl] diamino acids and dipeptide derivatives and studies of their antimicrobial activities and the effect of gamma rays on some of these compounds

The synthesis of different N, N'- [4,4-carbonyldiphthaloyl] diamino acids [II-IX] and some of their corresponding acid chlorides [X-XII] and methyl esters [XIII-XV] are described. Coupling of N, N'-[4,4- carbonyldiphthaloyl] diamino acids with amino acid methyl ester hydrochlorides in dioxan containing triethyl amino using the dicyclohexyl-carbodiimide [DCC] method furnishes the desired N, N'- [4,4'-carbonyldiphthaloyl] bis-dipeptide methyl esters [XVI-XXIV]. Most of the synthesized N, N'-[4,4'-carbonyldiphthaloyl] diamino acids, esters and bis-dipeptide methyl esters were found to be active against number of microorganisms. The effect of gamma irradiation on some of these compounds was studied