Testosterone and luteinizing hormones in impotent and infertile diabetic patients

This study comprised 29 diabetic patients, divided into 3 groups; 12 non complicated, 5 infertile and 12 impotent diabetic patients, in addition to 5 healthy normal males of matched age. All cases were subjected to thorough clinical examination, fasting and post prandial blood sugar, semen analysis for infertile group and radio immunoassay of serum testosterone and luteinizing hormones. It was found that, neuropathy and peripheral ischaemia were more common in the impotent diabetic group. Serum testosterone was significantly subnormal in the impotent group, but the luteinizing hormone was significantly subnormal in infertile one. The emperical use of androgen and luteinizing hormone in diabetics with sexual problems is not advisable as it could further depress the hypothalamopituitary gonadal axis

Effect of diuretics on some respiratory function tests in bilharzial patients with and without ascites

This work comprised 20 male bilharzial patients, devided into 2 groups, 10 bilharzial patients without ascites, 10 patients with ascites and in addition, 10 healthy subjects as a control group. All cases were subjected to thorough history taking, complete clinical examination and the following investigations: urine and stool analysis, blood urea, serum creatinine, x-ray chest, electrocardiography and ventilatory function tests particulary 1C, ERV, FVC, FEV[1], MVV, FMEF, FMEFT, FEF and AVI. Percutaneous transsplenic portal manometry was done for nonascetic and ascitic group, and the intraperitoneal presure was measured for ascitic group only. Bilharzial patients without ascites have obstructive ventilary defect only, while patients with ascitis has combined obstructive and restrictive defects, and diuretics improved these defects. There is negative correlation between portal venous pressure and intraperitoneal pressure and all ventilatory function tests except FMEFT where the correlation is positive. From the preceeding we can see that diuretics are of value in improving organ funciton not only in the ascitic bilharzial patients but also in the non ascitic cases and wherever oedema is interferring with function i.e. interference with digestion in patients with portal hypertension or ascites, and interference with ventilation due to oedema of the bronchial mucosa

Combined drug therapy of intestinal bilharziasis with and without polyposis

In endemic areas treatment of intestimal schistosomiasis, especially when complicated with polyposis, is a major medical problem. In the past few years introduction of new drugs gave hope for treatment of such cases. These drugs were mainly niridazole and oxamniquine. Niridazole has to be given repeatedly at two months intervals over a period up to one year. Oxamniquine provides the advantage of short term therapy over 3 days but the cure rate was much lower than niridazole. The two drugs are different pharmacolozically and this encourages us to give both drugs in succession, then simultaneously without accentnation of the side or toxic effects than when either drug was given alone. In this study 493 patients of intestinal bilharziasis, 39 of them with bilharzial colonic polyposis were included, using different schedules of therapy. Niridazole in a dose 4 mg/ kg. B. W. daily for 20 days and oxamniquine 60 mg/kg. B.W. as a total dose divided over 3 days. The best results were obtained when both drugs were given simaltaneously. The cure rate in non polypotic bilharzial cases was 96.5% and in patients with plyposis 64.3%, while the cure rate using oxamniquine alone or using the two drugs in succession starting by either of them gave much less cure rate, [not more than 40%]. We can conchude that the best treatment of intestinal schistosomiasis with or without polyposis is the simultaneous administration of oxamniquine and niridazole in the above mentioned dosage schedule

Relation between clinico-radiological grading and respiratory functions in bilharzial corpulmonale

This work comprised 18 patients with variable degrees of bilharzial corpulmonale and 18 control subjects of different age and sex. They were subjected to thorough clinical examination and different laboratory, radiological, electro-cardiographic and pulmonary function investigations. It was found that, respiratory functions was impaired in patients with bilharzial corpulmonale, both restrictive and obstructive ventilatory dysfunctions. The clinical grading gives an diea about the obstructive dysfunction while radiological grading given an idea about the restrictive ones. On the other hand the clinical grading more or less equal to the radiological grading, So, the clinical examination can tell us abuot the expected radiological findings in those patients

Evaluation of cases with pyrexia of unknown origin [P.U.O.]

Twenty two cases of P.U.O. were sleeted out of 698 inpatients at Mansoura Fever Hospital. Through clinical examination, laboratory investigations follow up were undertaken to reach the possible etiological diagnosis. It was found that, the commonest cause of pyrexia among the whole cases wase upper respiratory tract infections, followed by infective hepatitis and then enterica. P.U.O. represent at least 3.15% of the whole febrile inpatients. Infection is a very important preventalbe group in Egypt [50%]. Schistosomiasis has been found among the causes of P.U.O. in our locality. The emperical use of antibiotics should be prohibited in P.U.O. before doing blood picture, Widal test, urine and stool analysis