Résumé
Objective: To assess the association between hypertension and chronic renal failure with lethal effects of chromium on the beginning of the Chronic Kidney disease
Study Design: A prospective cross sectional study
Place and Duration of Study: Jinnah post graduate medical centre and Kidney centre Karachi during December 2012 to December 2013
Materials and Methods: The present study was conducted on a total of 150 patients [age > 40 years] divided into three groups. Patients in Group I included 50 patients with hypertension whereas Group II included 50 patients with hypertension associated with chronic renal failure [CRF] and Group III consisted of 50 healthy controls
Results: Results showed that levels of fasting blood sugar and HbA1c in both group I and group II weresignificantly higher as compared to controls. The levels of serum urea [132.0 +/- 28.2] and creatinine [7.8 +/- 1.38] in group II patients were significantly high as compared to group I and group III patients. The Creatinine clearance [55.1 +/- 9.61] in group II patients were significantly less as compared to group I and group III patients. Serum chromium levels were significantly high in group II patients[59.6 +/- 6.73]as compared togroup I andcontrols
Conclusion: Serum chromium level has significant correlation with glycemic index in both group I and group II patients compared to controls, while correlation with renal failure was significant only in group II patients