Role of prophylactic ondansetron for prevention of spinal anaesthesia induced hypotension in lower segment caesarean section

Objective: To determine the efficacy of prophylactic administration of intravenous Ondansetron for prevention of spinal anaesthesia induced hypotension in lower segment caesarean section

Study Design: Double blinded randomized controlled trial

Place and Duration of Study: It was conducted in Anesthesiology department, CMH Rawalakot; from 3 Mar to 4 Jun 2014

Material and Methods: One hundred patients were selected for this study, and randomly divided in two groups of 50 each, using random numbers table. Both groups were preloaded with Ringer's lactate at dose of 10ml/kg. Group A received 04 mg of IV ondansetron 5 min prior to spinal anaesthesia, whereas Group B received normal saline 05 minutes before administration of Spinal Anaesthesia

Results: Average age of Group A was 28.62 +/- 4.64 years, whereas that of Group B was 27.88 +/- 3.98 [p-value= 0.394]. Average weight of Group A was 70.30 +/- 6.25 kg, whereas that of Group B was 70.74 +/- 6.17 kg [p-value= 0.724]. Hypotension was noted in 21 patients in group A [42%], whereas it was observed in 34 Patients in Group B [68%] [p-value= 0.009]. Bradycardia was noted in 9 patients in Group A [18%] and 19 patients in Group B [p=0.026]

Conclusion: Intravenous administration of 04 mg of intravenous ondansetron, 05 minutes prior to subarachnoid block, is effective in decreasing frequency of hypotension

Cholesteatoma; its complications

OBJECTIVE: To find out the incidence of various extracranial and intracranial complications in the patients having chronic suppurative otitis media with cholesteatoma. DESIGN: Study of 40 patients having various extracranial and intracranial complications due to chronic suppurative otitis media with cholesteatoma. SETTING: Department of ENT, Mayo Hospital, Lahore PERIOD: 1st January, 1995 to 30th December, 1997. PATIENTS AND METHODS: This study was carried out on 40 patients having chronic suppurative otitis media with cholesteatoma. The incidence of various extracranial and intracranial complications found in these patients was recorded. Thirty patients [75%] presented with extracranial complications. The most common extracranial complication was postaural fistula [35%] followed by mastoid abscess [20%] and facial paralysis [15%]. Ten patients [25%] presented with intracranial complications. The most common intracranial complication was brain abscess [10%] followed by extradural abscess [7.5%] and meningitis [5%]. Twelve patients [30%] presented with more than one complications. Chronic suppurative otitis media with cholesteatoma is a dangerous condition. It can lead to various extracranial and intracranial complications. More patients present with extracranial complications than the patients presenting with intracranial complications. Some patients present with more than one complications