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1.
Rev. méd. Chile ; 144(8): 965-971, ago. 2016. ilus, tab
Article Dans Espagnol | LILACS | ID: biblio-830600

Résumé

Background: Smoking cessation therapies include counseling, psychological management and pharmacological therapy. Varenicline is the most effective and safe medication available. Aim: To study risk factors for the failure of pharmacological smoking cessation therapy with varenicline. Patients and Methods: Retrospective analysis of 281 patients aged 45 ± 11 years (65% males) with a mean consumption of 31 ± 22 packs/year. They completed a smoking cessation program comprising psychological support and use of varenicline in a private clinic. Patients were followed with telephonic interviews during one year. A complete abstinence during one year was considered as a success of the program. Results: The success rate of the program was 53.4%. The factors associated with failure were a high tobacco dependence rate determined with the Fageström test (Odds ratio (OR) 2.47, 95% confidence intervals (CI) 1.16-5.26, p = 0.02). An instruction level of more than 12 years was associated with a lower failure rate (OR 0.38 95% CI 0.18-0.82). Conclusions: A high tobacco dependence rate and a lower education were associated with a higher failure rate of this smoking cessation program.


Sujets)
Humains , Mâle , Femelle , Adulte , Adulte d'âge moyen , Sujet âgé , Évaluation de programme , Fumer/traitement médicamenteux , Arrêter de fumer/méthodes , Agonistes nicotiniques/usage thérapeutique , Varénicline/usage thérapeutique , Fumer/effets indésirables , Fumer/psychologie , Méthodes épidémiologiques , Résultat thérapeutique , Arrêter de fumer/psychologie , Âge de début , Niveau d'instruction , Programmes nationaux de santé/normes
2.
Rev. méd. Chile ; 141(3): 345-352, mar. 2013. ilus
Article Dans Espagnol | LILACS | ID: lil-677343

Résumé

Background: Therapies to quit smoking are based on counseling, psychological therapy (PT), nicotine replacement therapy, bupropion or varenidine. Aim: To report the results of a multidisciplinary program to quit smoking Material and Methods: Patients agedl8years or more, motivated to quit smoking were admitted in a program based in counseling and PT, with or without pharmacological therapy. They were assessed by telephone during one year offollow up. Patients with unstable psychiatric diseases were excluded. Results were considered as "successful" when patients maintained abstinence during the year offollow up. A logistic regression analysis was done to identify factors associated with treatment success. Results: Between 2005 and 2011, 198 patients aged 45 ± 11 years (56% males), who smoked 31.5 ± 20.6 packages/year, were treated. Ofthese, 155 (78%) were treated with varenidine, 26 (13%) with bupropion and 17 (9%>) did not receive pharmacological therapy. One hundred sixty eightpatients completed the year offollow up. In 82 (49%>), treatment was successful and was negatively associated with a history of depression (odds ratio = 4 (95% confidence intervals 1.23-38.33). The main side effeets associated to varenidine and bupropion were nausea in 37 and 23%o, sleep disorders in 20 and 19%o and headache in 12 and 0%>, respectively Conclusions: A multidisciplinary program to quit smoking achieved a 49%> of abstinence during a year offollow up.


Sujets)
Adolescent , Adulte , Sujet âgé , Femelle , Humains , Mâle , Adulte d'âge moyen , Jeune adulte , Benzazépines/usage thérapeutique , Bupropion/usage thérapeutique , Thérapie cognitive , Agonistes nicotiniques/usage thérapeutique , Équipe soignante , Quinoxalines/usage thérapeutique , Arrêter de fumer/méthodes , Fumer/thérapie , Benzazépines/effets indésirables , Bupropion/effets indésirables , Association thérapeutique/méthodes , Études transversales , Agonistes nicotiniques/effets indésirables , Évaluation de programme , Quinoxalines/effets indésirables , Facteurs socioéconomiques , Résultat thérapeutique
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