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1.
J Cancer Res Ther ; 2006 Oct-Dec; 2(4): 161-5
Article Dans Anglais | IMSEAR | ID: sea-111383

Résumé

BACKGROUND AND PURPOSE: A better understanding of appropriate sequencing and use of multimodality approach in the management and subsequent improvement in overall survival mandates a vigil on quality of life issues. Intensity modulated radiotherapy (IMRT) is a powerful tool, which might go a long way in reducing radiation doses to critical structures and thereby reduce long term morbidities. The purpose of this paper is to evaluate the impact of IMRT in reducing the dose to the critical normal tissues while maintaining the desired dose to the volume of interest for abdominal malignancies. MATERIALS AND METHODS: During the period January 2002 to March 2004, 11 patients of various sites of malignancies in the abdominal region were treated using physical intensity modulator based IMRT. Plans of these patients treated with IMRT were analyzed using dose volume histograms. RESULTS: An average dose reduction of the mean values by 50% to the liver, 57% to the right kidney, 56% to the left kidney, 66% to the cord and 27% to the bowel, with respect to the GTV could be achieved with IMRT. The two-year disease free survival was 79% and two-year overall survival was 88%. The average number of IMRT fields used was six. CONCLUSION: IMRT with inverse planning enabled us to achieve desired dose distribution, due to its ability to provide sharp dose gradients at the junction of tumor and the adjacent critical organs.


Sujets)
Tumeurs de l'abdomen/mortalité , Adulte , Sujet âgé , Survie sans rechute , Humains , Mâle , Adulte d'âge moyen , Dose de rayonnement , Planification de radiothérapie assistée par ordinateur/méthodes , Radiothérapie conformationnelle/méthodes , Tomodensitométrie , Résultat thérapeutique
2.
Indian J Cancer ; 1997 Jun; 34(2): 77-83
Article Dans Anglais | IMSEAR | ID: sea-49422

Résumé

From 1980 to 1989, 145 patients of histologically proven adenocarcinoma of the endometrium were seen and treated at the Department of Radiotherapy, Postgraduate Institute of Medical Education and Research, Chandigarh, Majority of the patients (84/145) presented with FIGO stage I disease. Relationship of myometrial invasion to grade was highly significant (p < 0.001). One hundred and seven patients were treated by surgery in combination with pre-operative or post-operative radiotherapy. The importance of various prognostic factors was assessed and grade of the tumour had statistically highly significant effect on survival (p < 0.005). Postoperative radiotherapy is recommended in patients with poor prognostic factors.


Sujets)
Association thérapeutique , Survie sans rechute , Tumeurs de l'endomètre/mortalité , Femelle , Humains , Adulte d'âge moyen , Pronostic , Études rétrospectives
3.
Article Dans Anglais | IMSEAR | ID: sea-65731

Résumé

Twenty five patients with squamous cell carcinoma arising from the middle third of the esophagus were treated radically, with external radiation, to a dose of 55-60 Gy. All patients had lesions less than 6 cm in length with no extra-esophageal spread on computed tomography scan. Eleven of these patients received additional intracavitary radiation to a dose of 12 Gy, 1 cm from the source axis in two sessions of 6 Gy each, a week apart. There was no significant difference in the relief of dysphagia and survival among these receiving and those not receiving intracavitary radiation. Addition of intracavitary radiation to radical external radiation was associated with significant complications like stricture and fistulae formation, which accounted for the poor results.


Sujets)
Curiethérapie/effets indésirables , Carcinome épidermoïde/mortalité , Troubles de la déglutition/prévention et contrôle , Tumeurs de l'oesophage/mortalité , Sténose de l'oesophage/étiologie , Études d'évaluation comme sujet , Humains , Radiothérapie/effets indésirables , Dosimétrie en radiothérapie , Fistule trachéo-oesophagienne/étiologie
4.
Indian J Chest Dis Allied Sci ; 1991 Oct-Dec; 33(4): 195-200
Article Dans Anglais | IMSEAR | ID: sea-29525

Résumé

There is no systematic study available from our country regarding pulmonary function tests in patients of breast cancer who receive postoperative radiotherapy. Therefore, we planned a prospective study to find out the effect of radiation on pulmonary functions in patients with breast cancer; who had undergone surgery in the form of simple mastectomy and axillary clearance. Transient radiological changes were seen in two cases and one patient had fibrosis at 9 months.


Sujets)
Tumeurs du sein/radiothérapie , Humains , Poumon/effets des radiations , Études prospectives , Lésions radiques/épidémiologie , Respiration/effets des radiations
5.
Article Dans Anglais | IMSEAR | ID: sea-65579

Résumé

Nine patients with advanced squamous cell carcinoma of the middle third of the esophagus were treated by high dose rate intracavitary therapy. The dose delivered was 12 Gy in two sessions at 1 cm from the center of the source. All nine patients were alive after 9 months. Six months after treatment, 4 patients had strictures which were dilated. At the end of nine months, 6 patients had dysphagia, four of whom had strictures and two had recurrence which was treated by further intracavitary irradiation. Intracavitary radiation using high dose rate, remote controlled afterloader has a significant role in palliation in patients with advanced esophageal carcinoma and avoids intubation.


Sujets)
Curiethérapie , Carcinome épidermoïde/anatomopathologie , Tumeurs de l'oesophage/anatomopathologie , Études d'évaluation comme sujet , Études de suivi , Humains , Soins palliatifs/méthodes , Projets pilotes , Dosimétrie en radiothérapie
8.
Indian J Cancer ; 1978 Jun; 15(2): 63-7
Article Dans Anglais | IMSEAR | ID: sea-50496
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