Résumé
Introduction: Infertility is defined as the inability of a couple to achieve pregnancy over an average period of one year [in women under 35 years of age] or 6 months [in women above 35 years of age] of unprotected sexual intercourse. Infertility can be due to female, male reasons or both. It can be either primary or secondary
Aim of the work: The aim of this study is to evaluate the association between thyroid function and serum AMH levels
Methodology: Type of the study: this study was conducted a case control study. Study site: This study was carried out at Ain-Shams maternity hospital [outpatient infertility clinic]. Duration of study: In the period between December 2015 and December 2016. Patients and study design: According to the sample size calculation by using the IBM Sample Power Software [IBM Corp., Armonk, NY, USA], the study performed on 128 women divided into 2 equal groups as follows: Group "1" [study group]: 64 infertile women at reproductive age [20-35] years. Group "2" [Control group]: 64 normal fertile women aged [20- 35] years
Result: TSH and patient age that were strongly correlated with AMH levels in 26 post-matched infertile patients using multivariate logistic regression. Both TSH levels and patient age significantly impacted AMH levels in infertile patients
Conclusion: AMH levels were inversely correlated with TSH levels in infertile women of reproductive age
Recommendations: The study should be done using larger sample sizes in a multicenter trial including both urban and rural areas to validate results. Autoimmune thyroid antibodies [thyroglobulin antibody and thyroid peroxidase antibody] could be assessed with TSH, FT4, FT3 and AMH as there is a strong association between infertility and autoimmune thyroid antibodies