Résumé
Background: Millions of people suffer from acute coronary syndrome, angina, acute myocardial infarction [MI], or related illnesses. These patients are prescribed nitroglycerin [NG] for the management of these diseases. Accordingly, any risk associated with the use of nitroglycerin can potentially affect those people despite of the undeniable benefit in relieving acute angina
Aim of the present work: was to study the potential of treatment with 3 different doses of NG [25, 50, 100 mg/kg] to develop nitrate tolerance
Materials and Methods: 50 Male Albino rats were randomly divided into 2 main groups: sham group and ischemia/reperfusion [I/R] groups, which was further subdivided into 4 groups, Untreated group; NG 25, 50 and 100 mg groups; rats received nitroglycerin three times daily for 3 days before induction of ischemia reperfusion. The effect of NG on cardiac functions and infarction size and severity score were assessed
Results: Rats exposed to I/R exhibited a significant decrease in their cardiac hemodynamic functions [[upwards arrow] left ventricular end diastolic pressure; LVEDP and [downwards arrow]dp/dt[max]] and development of a measurable cardiac infarction area. Regarding pretreatment with NG; NG 25 mg/kg improved cardiac functions and myocardial infarction size and severity score. NG 50 mg/kg significantly decreased myocardial contractility and increased myocardial infarction size. Meanwhile NG 100 mg/kg produced significant decrease in cardiac functions and significant increase in myocardial infarction size and severity score
Conclusion: NG pretreatment dose dependently decreased cardiac hemodynamic functions and increased myocardial infarction size and severity score in a rat model of ischemia reperfusion