The effects of antioxidant belaf drug on the activities of rabbits poisoned by a single acute dose of methamidophos

16 adult healthy rabbits aged 12 months were divided into 2 groups. All of them were intoxicated acutely by methamidophos and the one used BELAF sulution, the other group was intoxicated by NaCl 0.9% solution. Results showed that a simple dose of methamidophos could reduce the antioxidant capacity, especially with the activity of red blood cell superocid dismutase and the concentration of reducing total antioxidation of rabbit plasma. However, these changes were recovered after 48 hours of the experiments. The recovered effect of BELAF was not manifested fully.

The relation between serum SCC levels and the disease stages of the patients with squamous cell cervical cancer

Objective: To evaluate the prognostic value of serum squamous cell carcinoma (SCC) antigen in cervical cancer patients. Serum SCC levels were measured in 222 cervical cancer patients, and were evaluated by statistical analysis. Results: 69.3% patients had serum SCC level >2µg/L and 25.2% had serum SCC level >10µg/L. The increase of serum SCC level is related to age, disease stages and could be a significant prognostic factor in cervical cancer

Activities of erythrocyte antioxidant enzynes and plasma total antioxidant of the patients with cervical cancer

By spectrometry, in 78 patients with uterine servical cancer and a control group of 45 healthy person, the activity of erythrocyte antioxidant enzymes and plasma total antioxidant was determined. Results showed a significant decrease of SOD enzyme and blood red cell GPX in cervical cancer patients versus that of the controls. There is a light decrease of total antioxidant state of plasma in patients with cervical cancer versus the controls, and of Hb level in patients with cervical cancer versus the controls. The results suggests a relation between the activity of antioxidant enzyme in cervical cancer patients and DNA damage due to oxygene stress

The changes of antioxidant potency of the patients with breast cancer in pre- and postradiotherapy

Study on 30 patients with breast cancer, from 40 to 57 years old in K hospital, Ha Noi. 30 healthy women in control group, from 45 to 57 years old. A significant decrease in activities of erythrocyte SOD, GPx and GR and plasma total oxidant status (TAS) was seen in breast cancer patients as compared to normal subjects. The parameters were significantly increased in breast cancer patients after operation as compared to those before operation. Plasma tumor marker CA 15,3 concentration was significantly increased in breast cancer patients as compared to normal subjects. The parameter was significantly decreased in breast cancer patients after operation as compared to those before operation, and it was also significantly decreased after radiotherapy as compared to those before radiotherapy. There was significantly negative correlation between erythrocyte SOD and GPx activity with plasma TAS concentration in the patients with breast cancer after radiotherapy