Effect of smilax glabra roxb on blood glucose of diabetic GK rat and on the isolated pancreas islets of normal rat

The ethanol extract of smilax glabra roxb (SG) (100mg/kg of body weight) reduced the blood level of glucose and plasma insulin levels of GK rat 4h after intraperitoneal administration (p< 0.01). While in the normal rat, it reduced only the glycemia. On isolated pancreas islets, SG concentration of 2mg – 4 mg/ml/h has no effect on insuline recretion. The finding suggests that hypoglycemic effect of SG is caused by the increase of the sensibility of target tissue to insuline.