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1.
Braz. j. med. biol. res ; 45(8): 777-783, Aug. 2012. ilus, tab
Article Dans Anglais | LILACS | ID: lil-643662

Résumé

We examined the capacity of high-intensity intermittent training (HI-IT) to facilitate the delivery of lipids to enzymes responsible for oxidation, a task performed by the carnitine palmitoyl transferase (CPT) system in the rat gastrocnemius muscle. Male adult Wistar rats (160-250 g) were randomly distributed into 3 groups: sedentary (Sed, N = 5), HI-IT (N = 10), and moderate-intensity continuous training (MI-CT, N = 10). The trained groups were exercised for 8 weeks with a 10% (HI-IT) and a 5% (MI-CT) overload. The HI-IT group presented 11.8% decreased weight gain compared to the Sed group. The maximal activities of CPT-I, CPT-II, and citrate synthase were all increased in the HI-IT group compared to the Sed group (P < 0.01), as also was gene expression, measured by RT-PCR, of fatty acid binding protein (FABP; P < 0.01) and lipoprotein lipase (LPL; P < 0.05). Lactate dehydrogenase also presented a higher maximal activity (nmol·min-1·mg protein-1) in HI-IT (around 83%). We suggest that 8 weeks of HI-IT enhance mitochondrial lipid transport capacity thus facilitating the oxidation process in the gastrocnemius muscle. This adaptation may also be associated with the decrease in weight gain observed in the animals and was concomitant to a higher gene expression of both FABP and LPL in HI-IT, suggesting that intermittent exercise is a "time-efficient" strategy inducing metabolic adaptation.


Sujets)
Animaux , Mâle , Rats , Carnitine O-palmitoyltransferase/métabolisme , Muscles squelettiques/enzymologie , Conditionnement physique d'animal/physiologie , Adaptation physiologique/physiologie , Lipoprotein lipase/métabolisme , Muscles squelettiques/métabolisme , Muscles squelettiques/physiologie , Oxydoréduction , Répartition aléatoire , Rat Wistar , Réaction de polymérisation en chaine en temps réel , RT-PCR
2.
Braz. j. med. biol. res ; 44(11): 1070-1079, Nov. 2011. tab
Article Dans Anglais | LILACS | ID: lil-604276

Résumé

Abstract The reduction of skeletal muscle loss in pathological states, such as muscle disuse, has considerable effects in terms of rehabilitation and quality of life. Since there is no currently effective and safe treatment available for skeletal muscle atrophy, the search for new alternatives is necessary. Resistance exercise (RE) seems to be an important tool in the treatment of disuse-induced skeletal muscle atrophy by promoting positive functional (strength and power) and structural (hypertrophy and phenotypic changes) adaptive responses. Human and animal studies using different types of resistance exercise (flywheel, vascular occlusion, dynamic, isometric, and eccentric) have obtained results of great importance. However, since RE is a complex phenomenon, lack of strict control of its variables (volume, frequency, intensity, muscle action, rest intervals) limits the interpretation of the impact of the manipulation on skeletal muscle remodeling and function under disuse. The aim of this review is to critically describe the functional and morphological role of resistance exercise in disuse-induced skeletal muscle atrophy with emphasis on the principles of training.


Sujets)
Humains , Force musculaire/physiologie , Muscles squelettiques/physiopathologie , Amyotrophie/thérapie , Entraînement en résistance/effets indésirables , Hypertrophie/thérapie
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