Two new compounds from rifamycin resistant mutant strain Streptomyces sp. HS-NF-1046R / 药学学报

Using silica gel column chromatography, gel chromatography and HPLC, we isolated secondary metabolites in fermentation broth of a rifamycin resistant mutation strain Streptomyces sp. HS-NF-1046R. Based on spectroscopic data, the chemical structures of three compounds were identified as 3-hydroxyl-2-N-propionyl- anthranilamide (1), 2,3-dihydro-8-hydroxy-2,2-dimethyl quinazolin-4-(1H)-one (2) and 2-aminobenzamide (3). Compounds 1 and 2, as new entities, were evaluated for cytotoxicity against A549, HepG2, HCT-116 and K562 cells using the SRB assay. Compounds 1 and 2 exhibited no cytotoxicity with IC50 over 100 μmol·L-1.

Efficacy comparison of tissue selecting therapy stapler and procedure for prolapse and hemorrhoids in the treatment of severe hemorrhoids / 中华胃肠外科杂志

<p><b>OBJECTIVE</b>To compare the efficacy and complication of tissue selecting therapy stapler (TST) and procedure for prolapse and hemorrhoids (PPH) in the treatment of severe hemorrhoids.</p><p><b>METHODS</b>Clinical data of 542 cases of severe hemorrhoids undergoing TST (258 cases) or PPH (284 cases) in The First Affiliated Hospital of Fujian Medical University from November 2010 to January 2012 were analyzed retrospectively. Operative parameters, efficacy and complication 3 months after operation were assessed and compared.</p><p><b>RESULTS</b>No significant difference in cure rate between TST and PPH (96.5% vs. 95.4%) was found, while the operation time and hospital stay after operation in TST group were significantly shorter urgency [(20.6±4.7) vs. (26.4±6.3) min, (2.9±0.5) vs. (3.5±0.7) d, both P<0.05]. Incidences of postoperative pain, bleeding, anal urgency and urinary retention in TST group were significantly lower than those in PPH group (all P<0.01). No anal stenosis was observed in TST group, and 5 cases developed anal stenosis in PPH group (P<0.05). Hemorrhoid recurrence did not differ significantly between the two groups.</p><p><b>CONCLUSIONS</b>The efficacy of TST and PPH is comparable for severe hemorrhoids patients, while TST is associated with faster postoperative recovery and less complications.</p>

Comparison of two kinds of procedures used in the removal of horizontal impacted mandibular third molars / 华西口腔医学杂志

<p><b>OBJECTIVE</b>To compare the effect of lingual split bone technique and high speed turbine bodkin boneless technique in the removal of horizontal impacted mandibular third molars.</p><p><b>METHODS</b>150 horizontal impacted mandibular third molars were randomly divided into two groups, 75 teeth in each group. One group received lingual split bone technique, while the other group received high speed turbine bodkin boneless technique. Both the operation time and operation complication were compared.</p><p><b>RESULTS</b>The operating time with lingual split bone technique and high speed turbine bodkin boneless technique were (35.85 +/- 6.05) min and (43.52 +/- 7.70) min (P < 0.05), respectively. There was significant difference of intraoperative fracture lingual film removal and facial swelling between lingual split bone technique and high speed turbine bodkin boneless technique (P < 0.05). While there was no significant difference of gingival laceration, postoperative pain, restriction of mouth opening and postoperative bleed between lingual split bone technique and high speed turbine bodkin boneless technique (P > 0.05). There was no lingual nerve injury or numbness of lower lip occurred in two kinds of procedures. Dry socket occurred in a case of high speed turbine bodkin boneless technique.</p><p><b>CONCLUSION</b>Lingual split bone technique is better in the removal of horizontal impacted mandibular third molars. It could shorten operation time and reduce the intraoperative and postoperative complications.</p>