Résumé
Objective: To prepare a series of polyethylene (PEG)-modified mesoporous silica nanoparticles (MSNs-PEG) used for danshensu delivery carrier. Methods: By the co-hydrolysis method with silica coupling agent, the content of the azide groups was controlled into MSNs. The structures of MSNs-PEG were characterized by FTIR, XRD, and TEM analyses. The results showed that PEG chains have been grafted on the surface of MSNs. The safety of MSNs-PEG carrier was preliminarily evaluated by MTT, the release rule of MSNs-PEG was investigated by in vitro release experiment. Results: PEG can be effectively and controlled grafted onto MSNs. The MSNs-PEG have the good stability in aqueous solution. The loading rate of MSNs-PEG was higher in the experimental results of danshensu. The drug loading and entrapment efficiency were 6.8 % and 22.8 %. The graft of PEG could change the release of the drug, which could effectively prolong the time of drug release. And with the increase of the amount of PEG (mass fraction), the release time of danshensu could be prolonged effectively. Conclusion: The click chemistry method is easy to control the PEG graft content, and effectively controls the release rate of danshensu.