Long-term oncological and surgical outcomes after Video Endoscopic Inguinal Lymphadenectomy (VEIL) in patients with penile cancer

ABSTRACT Objective: To report outcomes from the largest multicenter series of penile cancer patients undergoing video endoscopic inguinal lymphadenectomy (VEIL). Materials and Methods: Retrospective multicenter analysis. Authors of 21 centers from the Penile Cancer Collaborative Coalition-Latin America (PeC-LA) were included. All centers performed the procedure following the same previously described standardized technique. Inclusion criteria included penile cancer patients with no palpable lymph nodes and intermediate/high-risk disease and those with non-fixed palpable lymph nodes less than 4 cm in diameter. Categorical variables are shown as percentages and frequencies whereas continuous variables as mean and range. Results: From 2006 to 2020, 210 VEIL procedures were performed in 105 patients. Mean age was 58 (45-68) years old. Mean operative time was 90 minutes (60-120). Mean lymph node yield was 10 nodes (6-16). Complication rate was 15.7%, including severe complications in 1.9% of procedures. Lymphatic and skin complications were noted in 8.6 and 4.8% of patients, respectively. Histopathological analysis revealed lymph node involvement in 26.7% of patients with non-palpable nodes. Inguinal recurrence was observed in 2.8% of patients. 10y- overall survival was 74.2% and 10-y cancer specific survival was 84.8%. CSS for pN0, pN1, pN2 and pN3 were 100%, 82.4%, 72.7% and 9.1%, respectively. Conclusion: VEIL seems to offer appropriate long term oncological control with minimal morbidity. In the absence of non-invasive stratification measures such as dynamic sentinel node biopsy, VEIL emerged as the alternative for the management of non-bulky lymph nodes in penile cancer.

Laparoscopic Treatment of Vesicovaginal Fistula

Introduction Vesicovaginal fistula is a rare disease with great impact for the patients. Laparoscopic repair can be an interesting option in selected cases with goods results but few experience is reported.Objectives Detailed demonstration of our laparoscopic vesicovaginal fistula repair technique. Initial results for ten patients are provided Methods: We treated all cases by the same technique. The surgical steps were: Patient positioning in Lloyd-Davis; Cystoscopy and implant of guide wire on fistula and ureteral catheters (that was removed after procedure); Transperitoneal access and 4 or 5 ports in V or W shape; Opening the bladder wall; Dissection between bladder and vagina for tension free repair; Fistula resection; Vagina repair with Vicryl 3-0; Bladder repair with Vicryl 3-0; Peritoneum/omentum interposition; Positioning 20 Fr urethral catheter.Results Mean age was 50 years. Mean number of fistulas was 1,2. The most common etiology was gynecologic surgery (7). Mean operative time was 2,5 (1,8-3,2) hours. Mean blood loss was 150 (100-200)mL. Complication rate was 10% (one case of urinary infection treated conservatively). Mean hospital stay was 1,2 (1-2) days. Mean return to normal and activities was 20 (15-30) days. For nine patients mean sexual intercourse time was 3 (1-6) months. Success rate after 1 year was 90% (one case of recurrence in patient with previous radiotherapy). Mean follow-up was 36 (12-60) months.Conclusions Laparoscopic repair is feasible, reproducible and present all advantages of minimally invasive surgical procedure. Long term results are similar to conventional open approaches.

Expanded criteria for Video Endoscopic Inguinal Lymphadenectomy (VEIL) in penile cancer: palpable lymph nodes

Introduction Open inguinal lymphadenectomy is the gold standard for the treatment of inguinal metastasis in patients with penile cancer (PC). Recently the Video Endoscopic Inguinal Lymphadenectomy (VEIL) was proposed as an option to reduce the morbidity of the procedure in patients without palpable inguinal lymph nodes (PILN), however the oncological equivalency in patients with PILN remains poorly studied. The aims of this video are the demonstration of VEIL in patients with PILN and present the preliminary experience comparing patients with and without PILN. Materials and Methods The video illustrates the procedure performed in two cases that were previously underwent partial penectomy for PC with PILN. Data from the series of 15 patients (22 limbs operated) with PILN underwent VEIL were compared with our series of VEIL in 25 clinically N0 patients (35 limbs operated). Results The comparison between the groups with and without PILN found, respectively, these outcomes: age 52,45 × 53,2 years, operative time 126,8 × 95,5 minutes, hospital stay 5. × 3.1 days, drainage time 6.7 × 5.7 days, 9 resected lymph nodes on average in both groups, global complications 32% × 26%, cellulitis 4.5% × 0%, lymphocele 23% in both groups, skin necrosis 0% × 3%, myocutaneous necrosis 4.5% × 0%, pN+ 33% × 32%, cancer specific mortality 7% × 5% and mean follow-up 17.3 × 35.3 months. None of the variables presented p < 0.05. Conclusions VEIL is a safe complementary procedure for treatment of PC, even in patients with PILN. Oncological results in patients with PILN seem to be appropriate but are still very premature. Prospective multicenter studies with larger samples and long-term follow-up should be conducted to determine the oncological equivalence of VEIL compared with open surgery in patients with PILN. .

Correção laparoscópica de fístula vesicovaginal: relato de caso / Laparoscopic repair of vesicovaginal fistula: a case report

Apesar de constituírem complicação incomum, as fístulas vesicovaginais apresentam expressivo impacto na qualidade de vida dos pacientes. As abordagens minimamente invasivas têm ganhado mais espaço no tratamento de doenças geniturinárias. Ainda são poucos os relatos do acesso laparoscópico para correção das fístulas vesicovaginais. Relata-se aqui um caso de fístula pós-histerectomia tratada totalmente de forma laparoscópica com ótimo resultado. As vantagens do acesso laparoscópico, assim como alguns detalhes técnicos, são discutidos...

Despite being an uncommon complication, vesicovaginal fistulas have significant impact on patient quality of life. Minimally invasive approaches have gained more space in the treatment of genitourinary diseases. There are few reports on laparoscopic approaches for correction of vesicovaginal fistulas. This is a case report of a post-hysterectomy fistulatreated exclusively through laparoscopy with excellent results. The advantages of the laparoscopic approach, as well as some technical details, are discussed...

Prostatectomia retropúbica videolaparoscópica: experiência inicial / Laparoscopic retropubic prostatectomy: initial experience

Introdução: o tratamento cirúrgico da hiperplasia benigna da próstata inclui a ressecção transuretral e a prostatectomia suprapúbica, dependendo do volume prostático. O acesso videolaparoscópico criou alternativa minimamente invasiva à prosatatectomia suprapúbica convencional. Objetivo: avaliar a viabilidade da técnica aberta por via laparoscópica. Pacientes e métodos: entre junho de 2006 e outubro de 2009, 15 pacientes foram submetidos à prostatectomia retropúbica videolaparoscópica no tratamento da hiperplasia prostática benigna (HPB). O acesso videolaparoscópico foi utilizado como alternativa minimamenteinvasiva à adenomectomia aberta. Foram avaliadas as características dos pacientes, o volume prostático e as complicações no per e pós-operatórios imediato e tardio. Resultados: a idade média foi de 68 anos (62-75 anos); o peso prostático médio foi de 123 gramas (70-190 gramas); o tempo cirúrgico variou de 120 minutos a 220 minutos. A perda de sangue estimada foi de 450 mL na média, sendo necessária transfusão em apenas um paciente. A permanência hospitalar média foi de três dias. O tempo com sonda vesical de demora foi de seis dias; e o tempo de irrigação vesical de um dia em todos os pacientes. O estudoanatomopatológico confirmou o diagnóstico de HPB em todos os casos. Nas complicações pós-operatórias, um paciente apresentou infecção superficial da ferida operatória, com boa resposta à antibioticoterapia. Conclusões: a prostatectomia retropúbica laparoscópica parece ser procedimento seguro, que permite reproduzir os princípios da cirurgia aberta. Neste trabalho observou-se baixa taxa de complicações, similar à da literatura.

Introduction: The surgical treatment of benign prostatic hyperplasia includes transurethral resection and suprapubic prostatectomy depending on prostate volume. The laparoscopic access creates a minimally invasive alternative to conventional suprapubic prostatectomy. Objective: to assess the feasibility of the open laparoscopic technique. Patients and methods: Between June 2006 and October 2009, 15 patients underwent laparoscopic retropubic prostatectomy in the treatment of benign prostatic hyperplasia (BPH). Laparoscopic access was used as a minimally invasive alternative to open adenomectomy. Patient characteristics and prostate volume were assessed, as well as complications in the early and late perioperative and postoperative stages. Results: Mean age was 68 years (62-75 years), mean prostate weight 123 grams (70-190 grams). Time of surgery ranged from 120 to 220 minutes. Mean estimated blood loss was 450 mL and transfusion was required for one patient. Mean hospital stay was three days. Time with indwelling catheter was six days and time of bladder irrigation was of one day for all patients. Anatomicopathological studies confirmed the diagnosis of BPH in all cases.Among postoperative complications, one patient had a superficial surgical wound infection, which responded well to antibiotic therapy. Conclusions:Laparoscopic retropubic prostatectomy appears to be a safe procedure that reproduces the principles of open surgery. In this study we observed a low rate of complications, similar to previous studies.

Cistectomia radical videolaparoscópica com neobexiga ileal ortotópica: experiência inicial / Laparoscopy radical cystectomy with ileal orthotopic blad - der: A preliminary experience

Apesar de ser o padrão-ouro no tratamento dos tumores invasivos de bexiga, a cistoprostatectomia ainda apresenta significativo impacto na qualidade de vida dos pacientes. As abordagens minimamente invasivas têm ganhado cada vez mais espaço no tratamento das neoplasias urológicas. Ainda são poucas as séries na literatura sobre o acesso videolaparoscópico para confecção de neobexiga ortotópica após a cistoprostatectomia radical. Relata-se um caso de câncer invasor de bexiga tratado de forma laparoscópica com ótimo resultado. As vantagens do acesso laparoscópico, assim como alguns detalhes técnicos, são discutidas.

Although it is not considered a gold standard in treating invasive bladder tumors, cystoprostatectomy still has significant impacts on patients? life quality. The minimally invasive approaches have gained importance in the treatment of bladder neoplasia. There are sill few reports on the use of laparoscopy for providing orthotopic bladder upon radical cystoprostatectomy. This is a case report of invasive bladder cancer that was treated with laparoscopy and yielded optimal result. The advantages of laparoscopy and some technical details are herein discussed.

Fratura peniana: diagnóstico e tratamento / Penile fracture: diagnosis and treatment

A fratura do pênis é definida como a ruptura da túnica albugínea do corpo cavernoso que ocorre exclusivamente durante a ereção. O principal mecanismo de trauma é o intercurso sexual traumático. Devido ao baixo número de casos, alguns pontos do tratamento ainda são controversos, entretanto, é recomendada a intervenção cirúrgica imediata. Este estudo retrospectivo observacional realizado entre abril de 2006 e abril de 2008 descreve os resultados da abordagem cirúrgica em 11 pacientes com fratura peniana tratados no Hospital Alberto Cavalcanti - FHEMIG. Foram avaliadas as características dos pacientes, o mecanismo do trauma, o tipo da lesão e as complicações no per e no pós-operatório imediato.

Objectives: To review the diagnostic and therapeutic options in patients with penile fracture and describe our experience. Patients & Methods: From April 2006 through April 2008, eleven consecutive men with diagnosis of penile fracture were treated at "AlbertoCavalcanti" Hospital. The etiology, interval from injury to presentation, presence of associated injuries and immediate postoperative complications were evaluated. Results: All patients were submitted to surgical intervention and nine had the diagnosis confirmed.None of them had per-operative complications. One patient had skin infection in the post-operative period. Conclusions: Penile fracture can be clinically diagnosticated, the management should be surgical and immediate.

Implante de prótese peniana maleável: análise de 87 pacientes consecutivos / Malleable penile prothesis: analysis of 87 consecutive patients

Este é um estudo retrospectivo observacional que descreve a experiência com 87 pacientes submetidos a implante de prótese peniana em Serviço de Urologia. O acompanhamento foi feito no Hospital Governador Israel Pinheiro (HGIP) em pacientes operados entre junho de 1999 e fevereiro de 2006. Foram avaliadas as características dos pacientes, a etiologia da disfunção erétil e as complicações no per e pós-operatórios imediato e tardio do implante de prótese peniana maleável.

Efeito da secção hepática parcial e omentoplastia na regeneração hepática de cão / Effect of partial hepatic section and omentoplasty on liver regeneration in the dog

O tratamento e a morbi/mortalidade dos pacientes com traumatismo hepático dependem do mecanismo da lesão e da conduta terapêutica, que inclui acompanhamento clínico, hepatorrafia, omentoplastia e próteses. O presente trabalho avaliou a recuperação hepática em presença de omentoplastia após lesão cortante do fígado de cão. Foram utilizados 15 cães machos, mestiços, com peso variando entre 7kg e 12kg, anestesiados com pentabarbitúrico endovenoso e submetidos a corte longitudinal no lobo esquerdo, medindo 2,5cm de profundidade e 8cm de comprimento. Os animais foram divididos em três grupos (n=5): I - sem sutura (controle); II - sutura hepática apenas; III - sutura hepática com omentoplastia. O fio utilizado foi o categute cromado 4-0. Todos os animais do grupo I morreram no pós-operatório imediato, enquanto os cães dos grupos II e III suportaram bem os 28 dias de acompanhamento. Á relaparotomia dos grupos II e III, encontraram-se múltiplas aderências ao fígado, que apresentou aspecto normal. No grupo III, o omento introduzido no ferimento hepático havia sido expulso e estava apenas aderido à cápsula do fígado macroscopicamente normal. Á microscopia houve descontinuidade vascular e biliar entre os segmentos proximal e distal à hepatotomia. Os fenômenos cicatriciais foram mais exuberantes no grupo III, no qual se encontraram pequenas áreas do parênquima contendo fragmentos de omento. Concluindo, a omentoplastia facilitou o procedimento de reparo hepático, que, entretanto, não restabeleceu a contiguidade de vasos e ductos biliares