Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Article Dans Anglais | IMSEAR | ID: sea-159160

Résumé

A number of medicinal plants used for treatment of malaria in Tanzania have been documented, but information on their safety and efficacy is still based on traditional knowledge accumulated over years and not on pre-clinical and clinical evaluation. The present study aimed to assess the cytotoxic activity of extracts of selected plant species used for treatment of malaria in Tanzania. Ethanol extracts were evaluated for cytoxicity by using MTT assay on LLC-MK2 cells and by brine shrimp lethality assay. Forty five (93.75%) out of 48 crude extracts assessed using LLC-MK2 cells were non-cytotoxic while three extracts (6.25%) were cytotoxic with CC50 <30 μg/mL (cut-off point). In the brine shrimp assay 30 (65.2%) out of 46 extracts tested were non-toxic while 16 extracts (34.8%) were toxic (LC50 <100 μg/mL). Antiaris toxicaria stem bark extract was the most cytotoxic to mammalian cells. This study demonstrates that, most of the antimalarial plants tested were non-toxic. These observations corroborate with traditional healers’ claims that the herbal medicines used in their areas are safe. However, further studies using different toxicity models are suggested to further confirm their claims.

SÉLECTION CITATIONS
Détails de la recherche