Résumé
Case-control methodology was used to assess lung cancer risk from exposure to arsenic in air, employing data from former workers in different units at the Chuquicamata copper mine and smelter complex. Thirty two workers from this complex were identified among the lung cancer deaths that occurred in the northern region of Chile belween 1987 and 1991. Each case was matched on age and sex, with controls that had a similar date of enrolment in the company. Available data on arsenic concentrations in air for six work sites were compiled from 1952 to 1991 and these were used to categorize the workplaces: Administrative Area (1,6 µg/mü), Mine (2,3 µg/mü), Oxid Plant (3,1 µg/mü), Workshop and Services (9,8 µg/mü), Sulphur Plant (8,4 µg/mü) and Smelter (201,7 µg/mü). The results indicate an Odds Ratio of 5.7 (Fisher's p=0,016) of dying from lung cancer among workers of the smelter compared with the rest of the workers