Résumé
Objective: To estimate the serum levels of matrix metalloproteinases in oral squamous cell carcinoma patients and in healthy subjects
Methods: In this observational study, biopsy diagnosed oral squamous cell carcinoma patients [n= 38] were recruited from Mayo Hospital, Lahore during 2016 to 2017. Age and gender matched Controls [n= 38] were also included. Venous blood sample of each participant was drawn, serum separated and the levels of matrix metalloproteinases were measured by multiplex ELISA
Results: Serum levels of MMP-1, -8, -10, -12 and -13 in OSCC patients showed statistically significant increase as compared to control group [p < 0.01]. The MMP-12 predicted the presence of OSCC with highest AUC of 0.836 [95% CI [0.733 to 0.911]] for sensitivity and specificity of 80% and 78.9%, respectively for a cut-off value of 16.13 pg/ml
Conclusions: MMP-12 has been found to have significant sensitivity and specificity to qualify as a diagnostic biomarker