Effect of noise and crowding stresses on hypothalamic-pituitary-gonadal axis and protective effect of sulpiride drug in adult female albino rats

Noise and crowding are the most stressful factors which cause depressant effects on human beings, especially females.Therfore this study was aimed at clarifying their effects on hypothalamus pituitary gonadal axis hormones [luteinizing hormone [LH] and follicle-stimulating hormone [FSH], estrogen [E2]and progesterone as well as prolactin [PRL]and the possible protective effect of antidepressant drug;sulpiride. Sixty adult female rats were divided into six groups [10/each]: 1- Rats served as control, 2- Rats treated with sulpiride drug only, 3- Rats exposed to noise [90db, 3hr. per day] for 45 days, 4- Rats exposed to noise and treated with sulpiride drug, 5- Rats exposed to crowding and 6- Rats exposed to crowding and treated with sulpiride drug. Results: Noise and crowding stresses caused a significant decrease of estrogen [E2], progesterone [P], LH and FSH levels and high significant increase in PRL level. Sulpiride drug ameliorated these parameters changes except PRL level which showed a high significant level compared to control group. It is useful to use antidepressant drug [e.g. sulpiride] with people who are exposing to noise and crowding stress

Effect of noise and crowding related stress on serum level of cortisol ACTH, epinephrine and insulin in female albino rats

Noise and crowding are the most stressful factors for human beings.Study aimed to clarify their effect on cortisol, ACTH, epinephrine, insulin and the amelioration effectof Sulpiride. Thirty six female rats were divided into six groups [6/each]:1- Rats served as control, 2- Rats treated with Sulpiride drug, 3- Rats exposed to noise [90db, 3hr. perday] for 45 days. 4- Rats exposed to noise and treated with sulpiride drug, 5- Rats exposed tocrowding. 6- Rats exposed to noise and treated with Sulpiride drug. Noise and crowding stresses caused a significant increase of cortisol, ACTH and epinephrinewhile there was a significant decrease in insulin hormone. Sulpiride drug ameliorated theseparameters. it is useful to use Sulpiride drug with people who are exposing to noise and crowdingstress