Résumé
The antioxidant activity of alcoholic extract of Tribulus alatus was investigated by determination of blood glutathione, serum ascorbic acid and serum superoxide dismutase in rats. All groups treated with aerial parts without fruit, fruits and total herb showed a significant increase in all measured parameters [P<0.05]. Upon fractionation of the alcoholic extracts using solvents with different polarities, all fractions revealed a significant increase in serum superoxide dismutase [P<0.05]. On the other hand chloroformic fraction of aerial parts without fruit extract and ethylacetate fraction of fruits extract exhibited a significant increase in blood glutathione level. All fractions of fruits extract, chloroformic and ethylacetate fractions of aerial parts without fruit extract significantly increase the serum ascorbic acid concentration [P<0.05]
Sujets)
Animaux , Mâle , Antioxydants/pharmacologie , Extraits de plantes/pharmacologie , Superoxide dismutase/effets des médicaments et des substances chimiques , Glutathion/effets des médicaments et des substances chimiques , Évaluation préclinique de médicamentRésumé
Biological evaluation of natural preparations used for treatment of hair loss revealed that the saponifiable fraction was the active fraction. The main constituents of this fraction were palmitic, stearic saturated fatty acids and oleic and linoleic unsaturated fatty acids. Certain modifications were done to increase the activity by addition of Cantharidin or Pilocarpine to the most active subfraction of saponifiable matter. The superior effect on treating hair loss was shown with the formulation containing cantharidin than that which contain pilocarpine