Résumé
Objectives: To investigate hepato-protective effect of ethanolic leave extract of Raphanus sativus against atorvastatin induced hepatotoxicity in albino rabbits
Study design: Experimental study
Material and Method: This study conducted at department of Physiology and Pharmacology, University of Agriculture, Faisalabad. The ethanolic extract of Raphanus sativus was prepared for hepatoprotective effect against hepatotoxicity produced by atorvastatin
Results: The results were compared with normal and experimental control. Serum was tested for ALT, AST, Alkaline Phosphatase and Bilirubin along with histological studies. Ethanolic extract of Raphanus sativus with 100mg/kg. of body weight dosage developed some changes representing hepatotoxicity but higher doses showed an increase in toxicity as observed on histologic sections. A reduction in fibrosis and cholestasis was observed which needs further evaluation
Conclusion: Ethanolic extract of raphanus sativus did not show any amelioration in the increased enzymes level however a reduction in cholestasis was observed as represented by decreases in alkaline phosphatase levels also confirmed by histological studies
Résumé
Background: Hepatitis is a public health problem throughout the world. The chances of job-related exposure to hepatitis among healthcare workers is a key concern, particularly among students in healthcare profession
Methods: This six months [Jan to Jun 2017] cross-sectional study was carried out at Faisalabad Medical University, Faisalabad. Total 300 MBBS students [1st to 4th year] took part in this study. Data was collected using validated self-administered questionnaire. Descriptive statistics and Chi-square tests were used to find out the association between variables in the study
Results:Of 300 medical students, 40.6 percent were males and 59.4 percent were females. Female and older students demonstrated higher knowledge regarding hepatitis B and C, route of transmission, and availability of treatment for hepatitis B and C. Among them, 58.7 percent of males and 61.4 percent females had sufficient basic knowledge about hepatitis B and C. Moreover, 54 percent males and 57 percent females had good knowledge about sources for spreading of hepatitis while 54 percent males and 62 percent females had good knowledge regarding prevention against hepatitis. From total 300 students, 156 [52 percent] were vaccinated against hepatitis B. Lack of time was the most common reason reported for not being vaccinated against hepatitis B
Conclusion: The majority of participants in this study showed sufficient knowledge concerning HBV and HCV, route of transmission and prevention
Conclusion: It was concluded that CTG coupled with fetal blood sampling for fetal pH versus carditocography alone is an accurate method for assessment of fetal condition in labour to decide the mode of delivery and neonatal outcome after birth