Sujet(s)
Animaux , Mâle , Rats , Liquide de lavage bronchoalvéolaire/composition chimique , Lésion pulmonaire/anatomopathologie , Poumon/anatomopathologie , Pentoxifylline/pharmacologie , Facteur de nécrose tumorale alpha/effets des médicaments et des substances chimiques , Hormones corticosurrénaliennes/analyse , Gazométrie sanguine , Acide chlorhydrique , Instillation de médicaments , Numération des leucocytes , Lésion pulmonaire/induit chimiquement , Granulocytes neutrophiles/anatomopathologie , Protéines/analyse , Rat Wistar , Ventilation artificielleRÉSUMÉ
The effect of exposure to lead on endocrine function was studied in pubertal rats treated with 1.0 g/l lead acetate (PbAc) in drinkin water for 20 days (subacute group) or 9 months (chronic group) in addition to iv injections of PbAc (0.1mg/100g body weight) every 10(subacute group) or 15 days (chronic group). Although basal levels of testosterone were higher both in the plasma and in the testes of acuctely intoxicated animals, the ciruclating levels of lutinizing hormone (LH) were not affected in either group, nor was the LHRH content of the median eminence. The density of [125I]LH/hCG biding sites in testicular homogenates was reduced by saturnism in both groups. Howeverm the apparent affinity constant of the hormone-receptor complex significantly increased. These data can be viewed as the result of a mixture of specific lead toxicity (e.g., at the enzyme level) with other more general actions (e.g., at the level of the hypothalamus-pituitary-testicular axis)