Résumé
Natural honey is widely used all over the world as a complementary and alternative medicine in various disorders including gastrointestinal lesions. To evaluate the effects of combination of low dosage of honey [0.312 g/kg] and sucralafe [0.125 or 0.250 g/kg] on gastric protection and to determine any potentiating interactions between them against ammonia- induced gastric lesions in rats. Material and Twenty-four hours fasted rats were given 1ml of ammonium hydroxide 1% intragastrically and they were killed one hour later under deep ether anesthesia. the gastric lesion index was calculated according to the methods of Takaishi et al 1998.non protein sulfhydryls level was determined spectrophotometrically as described by Sedlak and Lindsay 1968. Administration of ammonium hydroxide produced red and black linear lesions ands significant depletion of gastric nonprotein sulfhydryls level. Oral administration of honey [0.312 g/kg] or sucralfate [0.12 and 0.250 g/kg] 30 min before ammonium hydroxide reduced the severity of gastric mucosal lesions by 11 or 10 and 52% respectively, and has shown the changes in nonprotein sulfhydryls level induced by ammonium hydroxide. Furthermore, pretreatment with a combination of a low dose of honey [0.312 g/kg] and sucralfate [0.125 g or 0.250 g/kg] afforded significantly greater protection [58 and 77%] than that obtained with either of them administered alone. The present results suggest potentiation of gastric protection effect of sucralfate by honey and this may have a clinical value in the treatment of peptic ulcer disease in Helicobacter pylori positive patients