Hepatoprotective activity of swertia chirata

Different extracts of the whole plant of Swertia chirata were analysed for hepatoprotective activity against CC1[4] induced hepatotoxicity in rats. The alcoholic extract showed significant activity, lowering the serum enzymes GOT and GPT in rats intoxicated with CC1[4]. The activity was comparable to that of silymarin which served the purpose of standard drug in this study

In vitro cytotoxic and antimutagenic effects of protein fractions of cynodon dactylon, aegle marmelos, ocimum sanctum and coleus aromaticususing DLA cell lines

With increasing knowledge of the stages of initiation and development in the natural history of neoplastic diseases and the multiple observations that such stages are likely to be ubiquitous in the natural history of all histogenetic types of neoplasm, it is becoming increasingly important to distinguish chemical agents that act selectively during one or the other of these stages. Several compounds, occurring in food, were tested for antimutagenic effect towards cigarette-smoke condensate [CSC] and Benz [a]pyrene[BaP]. Antimutagenicity was determined in the Salmonella/ microsome test, with tester strain TA 98, in the presence of rat-liver homogenate. The similarity in results for cigarette-smoke condensate and for BaP indicates that a general mechanism may be involved in the inhibition of CSC and BaP- induced mutagenicity

Synthesis and pharmacological studies of 1, 3-disubstituted malonic acids

A new series of 1, 3-disubstituted malonic acid compounds [I-IX] were prepared via the reaction of malonyl di-chloride with the selected amino acids [P-alanine, glycine and aspartic acid] and their ethyl and propyl esters respectively. Structure of all the synthesized compounds have been elucidated by I.R. Synthesized compounds were found to be pharmacologically active and showed sedative-hypnotic activity and positive behavioral changes