Résumé
[[18]F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water [[18O]H2O>95%] with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. Pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. This radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats
Résumé
Gallium-66 [T1/2= 9.49 h] is an interesting radionuclide that has potential for positron emission tomography [PET] imaging of biological processes in intermediate to slow target tissue uptake. Oxine has been labeled with this radioisotope in the form of [66Ga]gallium chloride for its possible diagnostic properties. Materials and methods: 66Ga was produced in the 30 MeV cyclotron [Cyclon-30, IBA] via the 66Zn[p,n]66Ga reaction.TLC was performed on polymer backed silica gel. A Gamma spectrometer HPGe detector was used for countings. After the bombardment, the production yield was 11.2 mCi/ m Ah. The [66Ga]Oxine complex was obtained at the pH=5 in phosphate buffer medium at 37°C in 10 minutes. Radio-TLC showed an overall radiochemical yield of 97% [radiochemical purity > 98%]. The chemical stability of the complex was checked in vitro with a specific activity of 896 mCi/ml. [66Ga]oxine can be used in diagnostic studies due to its suitable physico-chemical properties both in vitro and in vivo