Résumé
Background: There is a significant worldwide burden of Alcoholic Liver Disease (ALD). Both alcohol abuse and infection with hepatitis viruses can lead to liver disease. Alcohol and hepatitis viruses have synergistic effects in the development of liver disease. Thus, early detection of virus hepatitis and targeted interventions can improve prognosis in ALD.Methods: This cross-sectional study was conducted among 180 patients coming to Baroda medical college and SSG hospital, Vadodara having alcoholic liver disease were studied and evaluated for markes of viral hepatitis and its clinical and biochemical profile in alcoholic liver disease.Results: our study we had taken 180 patients of alcoholic liver disease out of which male were 92% and female were 8%. Prevalence of viral hepatitis was 27.7% in ALD patients. Out of which hepatitis E was 13% followed by hepatitis A 11%, hepatitis B 4.44% and least was Hepatitis C 0.5%. In clinical profile fever was significantly higher in patients of viral hepatitis with ALD than patients without viral hepatitis. Bilirubin was not significant differ in both groups of patients but SGOT and SGPT had higher values in patients of viral hepatitis with ALD and thus ratio of SGOT/SGPT was also affected due to higher value of SGOT and SGPT.Conclusions: Alcohol consumption and hepatitis virus infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. Patients starting treatment for chronic viral hepatitis infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefit from additional support during antiviral therapy specially in chronic hepatitis
Résumé
Background: Surgical diabetes is syndrome of hyperglycemia and disturbance of carbohydrate, fat and protein metabolism associated with absolute or relative deficiency of insulin secretions. Diabetes mellitus and hypertension considered as a major medical and public health issues worldwide, and both are important risk factors for both macrovascular and microvascular diseases like coronary artery disease, heart failure and cerebrovascular diseases.Methods: This cross-sectional study was conducted among 175 patients coming to Govt. medical college and SSG hospital, Vadodara from 2014 to 2015 having diabetes mellitus were studied and evaluated for hypertension and its various risk factor like age, obesity.Results: one hundred and twenty-nine (127) out of 175 subjects had hypertension, thus giving a prevalence rate of 73.7% of which 64 males (49.6%) were hypertensive compared with 65 (50.3%) females. Mean age of patients having hypertension with Diabetes Mellitus (case) is 59.87 compare to DM without hypertension (control) was 56.21. Mean BMI in diabetes cases with hypertension was 30.93 while without hypertension was 23.47 suggest obese are more prone to develop hypertension. Waist hip ratio DM with hypertension was 0.96 while was 0.81 in DM without hypertension.Conclusion: Hypertension and its associated risk factor like obesity, dyslipidemia are important risk factor for development of complication in diabetes patients so early detection and intervention measures should be undertaken for aggressive control of blood pressure control , obesity and it will likely to offer the greatest promise for reducing the incidence of complications and its associated mortality.