Résumé
Background: Central nervous system lesions can have varied aetiology like infectious, inflammatory and neoplastic. Establishing an accurate aetiology is essential for timely diagnosis and neurosurgical intervention. The annual incidence of tumours of CNS ranges from 10 to 17 per 100,000 people for intracranial tumours and 1 to 2 per 100,000 people for intraspinal tumours; the majority of these are primary tumours, and only one fourth to one half are metastastic. The present study attempts to provide preliminary data on morphological patterns of intracranial lesions and to study clinicopathological spectrum.Methods: The present study was carried out at a tertiary care center from January 2015 to September 2017. A total of 65 cases of CNS lesions were analyzed. In case of CNS tumours reporting were done according to WHO criteria for classification and grading.Results: Out of 65 cases studied, 51 cases (78.46%) were of neoplastic lesions and 14 cases (21.54%) of non-neoplastic lesions. Among 14 cases of non-neoplastic lesions 2 cases were of reactive/cystic lesions, 4 cases were of infective lesions, and 8 cases were of congenital lesions. In the present study, out of 51 neoplastic cases most common cases were of astrocytoma.Conclusions: The exact histopathological diagnosis of Central Nervous system lesions is essential to predict the prognosis and treatment. Management strategies and prognosis of tumours depends on the correlation of factors like the types, grades of tumours, its location, size and stage of development.
Résumé
Background: To determine the prevalence of HU in Indian subjects attending the HU screening camps and in subjects with type 2 Diabetes Mellitus (T2DM), Hypertension (HTN), and T2DM+HTN.Methods: This was a retrospective, non-interventional study where medical records of subjects attending HU screening camps across 592 locations in India, between June 2017 to May 2018, were analyzed.Results: A total of 197097 subjects (T2DM: 19.69%; HTN: 14.08%; T2DM+HTN: 21.60%) attended the screening camps. Mean age of the study participants was 48.43±13.38 years (Male: 53.80%). A total of 48606(24.66%) subjects had HU. In the overall population, a higher proportion of subjects with T2DM + HTN (7.36%) had HU in comparison to subjects with T2DM (5.63%) and HTN (4.25%) alone. Similar results were reported when the data was evaluated only in HU subjects (T2DM+HTN: 29.85%; T2DM: 22.82%; HTN: 17.22%). Proportion of HU subjects increased with age, with the maximum prevalence evident in subjects aged >50 years (12.94%), followed by 30-50 years (10.65%) and <30 years (1.07%). Gender-wise, a slightly higher proportion of males (14.13%) were found to be hyperuricemic than females (10.53%). Higher proportion of subjects with disease (T2DM and/or HTN) duration of 2-5 years were found to be hyperuricemic in comparison with subjects with disease duration of >5 years or <2 years. Similar results were reported when the data was evaluated in the overall HU subjects and by indication.Conclusions: Authors observed a high prevalence of HU among subjects attending HU camps and those with associated comorbidities. The prevalence of HU was higher in males and has an increasing trend with age. Furthermore, the prevalence of HU was observed to be higher in subjects with 2-5 years of duration of T2DM and/or HTN.
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Bilateral renal vein thrombosis (RVT) is a rare clinical condition. Acase of a patient initially presenting with fever with a diagnosisof Plasmodium falciparum malaria was further investigated and it was found to have bilateral RVT. The patient was successfullytreated with anti-coagulants and immunosuppressant.
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Background: Palliative care aims to relieve suffering in all stages of disease. We studied the effect of introducing palliative care early at diagnosis on patient reported outcome among patients of carcinoma cervix. Methodology: We assigned patients with advanced stage of carcinoma cervix to receive either early palliative care integration or standard oncologic care alone. Quality of life and overall health were assessed at baseline, 12 weeks and at 20 weeks with use of European Organisation for Research & Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) C-30 scale and EORTC QLQ Cx-24 scale. We studied the secondary outcomes related to emergency hospital visits, compliance to treatment and End of life interventions. Results: The difference in score of EORTC C-30 and EORTC QLQ Cx-24 scales amongst groups was statistically significant at 12 weeks (P<0.05). Group P patients had 100% compliance for treatment, as compared to patients from Group C, as 6 patients left treatment before conclusion. The difference in scores of Group P and Group C, for all EORTC C-30 and EORTC QLQ Cx-24 questions at 20 weeks were not statistically significant (P>0.05). Conclusion: Among patients with advanced stage of carcinoma cervix, early palliative care led to significant improvement in quality of life, overall health, emergency hospital visits, and admission at end of life.
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The present investigation involved the synthesis of novel ligand HL14 and its chelate complexes with Cu(II), Ni(II), Co(II), Mn (II) and Zn(II). The characterization studies of chelates were conducted using various physicochemical methods such as elemental analysis, conductometric studies, magnetic susceptibility, FT-IR, NMR and electronic spectral data. The stoichiometry of the complex has been carried out and found to be 1: 2 (Metal: ligand). An octahedral geometry around Co (II), Ni (II) and Mn (II), distorted octahedral geometry around Cu (II) and tetra hedral geometry around Zn(II) have been proposed. The antifungal activity of ligand and its metal chelates was performed against various fungi.